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Sci Rep:一个评估主动脉瓣狭窄患者预后的新型非侵入性指标

2020-05-27 xiangting MedSci原创

在保留LVEF的中重度AS患者中,dσ*/dtmax<2.8s-1与不良临床结局独立相关。

左心室(LV)整体收缩指数,dσ*/dtmax测量了压力标化LV壁应力的最大变化率。这项研究旨在描述不同严重程度并保留左心室射血分数(LVEF)主动脉瓣狭窄(AS)患者的dσ*/dtmax趋势,以及在中重度AS患者中dσ*/dtmax与临床结局之间的关系。

这里回顾性研究了2001年1月1日至2015年12月31日诊断的1738例AS患者(550例轻度,738例中度,450例重度),这些患者保留LVEF≥50%。尽管保留LVEF,但dσ*/dtmax随着AS严重程度的增加而恶化(轻度AS:3.69±1.28s-1,中度AS:3.17±1.09s-1,重度AS:2.58±0.83s-1,p<0.001)。dσ*/dtmax<2.8s-1与主动脉瓣置换、充血性心力衰竭住院和全因死亡率复合结局的风险较高相关(调整后危险比1.48,95%CI:1.25-1.77,p<0.001)。

总之,尽管保留了LVEF,但dσ*/dtmax随着AS恶化而下降。在保留LVEF的中重度AS患者中,dσ*/dtmax<2.8s-1与不良临床结局独立相关。

原始出处:

Hui Wen Sim. A new non-invasive index for prognosis evaluation in patients with aortic stenosis. Sci Rep. 30 April 2020.

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