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BMJ:成年后体重变化与死亡风险

2019-10-17 MedSci MedSci原创

研究认为,整个成年期的稳定肥胖、从年轻到成的体重增加以及从中年到晚年的体重减轻与死亡率的增加有关。研究结果表明,在成年后维持正常体重,特别是在成年早期预防体重增加对降低死亡风险有显著作用

近日研究人员考察了成年后体重变化与死亡率之间的关系。

研究考察了美国国家卫生和营养检查调查(NHAES)1988-94和1999-2014数据。36051名40岁或40岁以上的人,在基线时测量体重和身高,并回归其青年(25岁)和中年(基线前10年)体重。研究的主要终点为2015年12月31日之前的特定死亡率。

在12.3年的随访期间,有10500人死亡。与保持在正常体重的参与者相比, 从非肥胖到肥胖的年轻人和中年人的全因死亡率和心脏病死亡率分别高出22%(HR:1.22)和49%(1.49)。在此期间,体重指数的变化从肥胖到非肥胖与死亡风险无关。从成年中期到后期,肥胖到非肥胖的体重变化模式与全因死亡率(1.30)和心脏病死亡率(1.48)增加相关,而在此期从非肥胖型向肥胖型转变与死亡风险无显著相关。在成年后维持肥胖与所有原因死亡率增加的风险一致;青年至成年中期的危险度为1.72,青年至成年后期为1.61,成年中期到成年后期为1.20。

研究认为,整个成年期的稳定肥胖、从年轻到成的体重增加以及从中年到晚年的体重减轻与死亡率的增加有关。研究结果表明,在成年后维持正常体重,特别是在成年早期预防体重增加对降低死亡风险有显著作用。

原始出处:


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    2019-11-03 gaoxiaoe
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    2019-10-22 胖子医生

    学习了,

    0

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    2019-10-17 一个字-牛

    学习了谢谢分享

    0

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    2019-10-17 天地飞扬

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