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Diabetes Care:HbA1c筛查2型糖尿病风险

2012-08-29 高晓方 医学论坛网

   美国学者的一项研究表明,HbA1c分类处于糖尿病前期的超重/肥胖青少年出现相对于胰岛素敏感性的β细胞功能受损。在大规模流行病学观测和(或)干预研究中,HbA1c可用作评估2型糖尿病风险进展或好转的筛查工具。论文于2012年8月21日在线发表于《糖尿病护理》(Diabetes Care)杂志。    此项研究共纳入160例糖尿病前期(HbA1c 5.7%~6.5%)和44例HbA1c正常(&

   美国学者的一项研究表明,HbA1c分类处于糖尿病前期的超重/肥胖青少年出现相对于胰岛素敏感性的β细胞功能受损。在大规模流行病学观测和(或)干预研究中,HbA1c可用作评估2型糖尿病风险进展或好转的筛查工具。论文于2012年8月21日在线发表于《糖尿病护理》(Diabetes Care)杂志。

   此项研究共纳入160例糖尿病前期(HbA1c 5.7%~6.5%)和44例HbA1c正常(<5.7%)的超重/肥胖青少年。通过正糖高胰岛素钳夹技术对比肝脏和外周胰岛素敏感性,通过高糖钳夹试验对比β细胞功能。以处置指数判定β细胞功能。

  结果显示,与HbA1c正常者相比,糖尿病前期受试者的空腹血糖、胰岛素以及OGTT葡萄糖和胰岛素曲线下面积均显著升高,肝脏和外周胰岛素敏感性降低,相对于胰岛素敏感性β细胞功能降低。HbA1c正常和糖尿病前期受试者中分别有27%和41%伴有血糖代谢障碍。

  链接:

  HbA1c Diagnostic Categories and β-Cell Function Relative to Insulin Sensitivity in Overweight/Obese Adolescents



    

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    2013-05-05 Smile2680
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