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Am J Hypertens:血压晨峰患者与冠状动脉患病风险

2015-08-26 徐媛媛 MedSci原创

血压晨峰患者的独立预后意义尚不清楚。本项研究旨在探究老年高血压患者收缩压MS与冠状动脉发病风险的关系。研究人员收纳了1191名年龄在60-90岁的患有高血压的老年患者并对其进行了患者冠状动脉发病风险的评估。根据收缩压MS三分位数、倾斜度状况、杓型和非杓型组内特定收缩压MS三分位数对患者进行分组。在随访期间(9.1±4.9年,范围:0.4-20年),共有120名患者发生冠状动脉事件。整体来看,冠状动

血压晨峰患者的独立预后意义尚不清楚。本项研究旨在探究老年高血压患者收缩压MS与冠状动脉发病风险的关系。

研究人员收纳了1191名年龄在60-90岁的患有高血压的老年患者并对其进行了患者冠状动脉发病风险的评估。根据收缩压MS三分位数、倾斜度状况、杓型和非杓型组内特定收缩压MS三分位数对患者进行分组。

在随访期间(9.1±4.9年,范围:0.4-20年),共有120名患者发生冠状动脉事件。整体来看,冠状动脉事件风险与收缩压MS无显著相关性,然而非杓型患者风险显著高于杓型患者。在非杓型和杓型患者中,三分位数收缩压MS,冠状动脉事件与杓型相关,但与非杓型无关。调整各种变量后,Cox回归分析显示,第三分位的杓型收缩压MS(>23mmHg)患者(HR 1.912,95% CI 1.048-3.488,P=0.03)和非杓型患者(HR 1.739,95% CI 1.074-2.815,P=0.02)较收缩压(<23mmHg)的杓型患者冠状动脉事件风险更高。

以上研究结果显示,在杓型老年高血压患者中,高收缩压MS可以预测冠状动脉事件,但非杓型不能预测。独立于收缩压MS,非杓型患者仍显示有更高的冠状动脉发病风险。

原始出处

Pierdomenico SD1, Pierdomenico AM2, Di Tommaso R3, Coccina F3, Di Carlo S3, Porreca E4, Cuccurullo F4.Morning Blood Pressure Surge, Dipping, and Risk of Coronary Events in Elderly Treated Hypertensive Patients.Am J Hypertens. 2015 Jul 20

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    2015-11-20 feather89
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    2015-08-26 lovetcm

    这一点也是值得临床重视,尤其是晨起高血压,可能是,卒中等等

    0

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