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Sci Immunol:皮肤中这类细胞或可抗癌!

2017-04-15 枫丹白露 来宝网

在新出版的研究中,达特茅斯诺里斯癌症中心的研究人员发现,称为常驻记忆T细胞的独特免疫细胞,在预防黑素瘤方面表现非常出色。这项工作开始于一个问题——为什么发生自身免疫性疾病(称为白癜风)的黑色素瘤患者有如此好的预后。白癜风是针对正常健康黑色素细胞的自身免疫性皮肤病,导致斑点中皮肤色素沉着丧失。研究小组使用黑色素瘤和白癜风的小鼠模型发现,常驻记忆T细胞永久寄居在受白癜风影响的皮肤中,在那里它们杀死黑素

在新出版的研究中,达特茅斯诺里斯癌症中心的研究人员发现,称为常驻记忆T细胞的独特免疫细胞,在预防黑素瘤方面表现非常出色。这项工作开始于一个问题——为什么发生自身免疫性疾病(称为白癜风)的黑色素瘤患者有如此好的预后。白癜风是针对正常健康黑色素细胞的自身免疫性皮肤病,导致斑点中皮肤色素沉着丧失。研究小组使用黑色素瘤和白癜风的小鼠模型发现,常驻记忆T细胞永久寄居在受白癜风影响的皮肤中,在那里它们杀死黑素瘤细胞。虽然以前已知常驻记忆T细胞可预防皮肤病毒感染,但不知道它们可以对抗肿瘤。

研究由Mary Jo Turk博士领导,旨在了解为什么在治疗过程中发生白癜风的转移性黑色素瘤患者的生存期延长。使用白癜风的小鼠模型,Turk解释了为什么这种疾病可能与更好的临床反应相关联。该研究首次证明,由于自身免疫性白癜风,常驻记忆T细胞是响应于肿瘤而产生的,并且在保护未来肿瘤方面发挥关键作用。他们的研究“皮肤介导的记忆性T细胞介导对黑色素瘤的耐久性免疫”将在下一期的“科学免疫学”(Science Immunology)上发表。

这个发现是令人惊讶的,因为抗癌的T细胞以前被认为只存在于免疫器官如脾脏,淋巴结和血液中,并从血液中进入肿瘤。Turk说:“我们的研究通过显示肿瘤杀伤性T细胞已经存在于皮肤中,可以快速反应和杀死黑素瘤细胞,来挑战这一长期的信念。虽然这些目前的研究仅限于小鼠,但类似细胞的存在可能解释了为什么白癜风患者如此好地保护黑色素瘤,并且存活时间更长。Turk和她的团队计划在人类患者中寻找这些细胞。

“虽然我们已经表明这些T细胞可以杀死皮肤黑色素瘤,但我们仍然需要确定它们是否存在于其他器官,如有转移性黑色素瘤生长的肺。” Turk说。 “由于我们的研究确定,常驻记忆T细胞对于保护肿瘤是至关重要的,而皮肤中的T细胞对黑素瘤提供长期免疫力,所以这种细胞的产生应该是未来癌症治疗的目标。”

原始出处:

Brian T. Malik, et al.  Resident memory T cells in the skin mediate durable immunity to melanoma.  Science Immunology  14 Apr 2017:Vol. 2, Issue 10, eaam6346.DOI: 10.1126/sciimmunol.aam6346


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    2017-04-26 jerrysam

    长知识

    0

  2. 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    2017-04-22 幸运8355

    非常好,学习了

    0

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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-20 幸运8355

    感谢分享,非常好

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Wed Apr 19 19:30:57 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188792, encodeId=928b188e92f4, content=将白癜风患者的记忆T细胞选出来, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Apr 19 11:57:39 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188563, encodeId=fb4b18856365, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-19 幸运8355

    感谢分享,是非常好

    0

  5. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), 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    2017-04-19 cqykthl

    将白癜风患者的记忆T细胞选出来

    0

  6. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-18 幸运8355

    学习了,谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Wed Apr 19 19:30:57 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188792, encodeId=928b188e92f4, content=将白癜风患者的记忆T细胞选出来, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Apr 19 11:57:39 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188563, encodeId=fb4b18856365, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-17 幸运8355

    非常好,谢谢分享

    0

  8. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-16 幸运8355

    学习了,谢谢分享

    0

  9. 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content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-16 大爰

    学习了谢谢分享!

    0

  10. 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createdTime=Sat Apr 22 18:49:03 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189175, encodeId=2aca1891e5c7, content=感谢分享,非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Thu Apr 20 22:38:01 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188882, encodeId=90f5188882ac, content=感谢分享,是非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Wed Apr 19 19:30:57 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188792, encodeId=928b188e92f4, content=将白癜风患者的记忆T细胞选出来, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Apr 19 11:57:39 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188563, encodeId=fb4b18856365, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Apr 18 18:10:39 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188294, encodeId=957a188294a6, content=非常好,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Apr 17 20:23:46 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187931, encodeId=573f18e93109, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Apr 16 16:38:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187841, encodeId=f68a18e84178, content=学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Apr 16 07:55:03 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187762, encodeId=82fb18e762da, content=很好,增长了知识!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:59 CST 2017, time=2017-04-16, status=1, ipAttribution=)]
    2017-04-16 明天会更好!

    很好,增长了知识!!!

    0

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