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EUR HEART J:肥胖与主动脉瓣狭窄发病率有关系吗?

2017-07-26 MedSci MedSci原创

近日,在医学权威杂志EUR HEART J 上面发表了一篇研究文章,研究人员旨在研究整体肥胖和腹部肥胖相关的主动脉瓣狭窄(AVS)发病率。

近日,在医学权威杂志EUR HEART J 上面发表了一篇研究文章,研究人员旨在研究整体肥胖和腹部肥胖相关的主动脉瓣狭窄(AVS)发病率。

研究人员采用前瞻性队列研究方法。研究人员收集了瑞典男性队列和瑞典乳房x光检查队列的数据,包括71817名无心血管疾病的男性和女性,并在1997年报告了他们的人体测量措施。通过全国范围内住院和死亡原因的登记,研究人员确定了主动脉瓣狭窄病例。研究人员利用Cox比例危险回归分析数据。

在平均15.3年的随访中,有1297例患者出现主动脉瓣狭窄(AVS)(男性771例,女性526例)。研究人员分别测量整体肥胖和腹部肥胖者的身体质量指数(BMI)和腰围,发现其与AVS发病率有关,且在男性和女性中相似。与体重指数18.5-22.5 kg/m2相比,超重者(体重指数25.0-29.9 kg/m2)的多变量风险比为1.24(95%可信区间[CI]:1.05 -1.48);肥胖(体重指数≥30 kg/m2)的多变量风险比为25.0(95% CI: 1.47-2.23)。与正常腰围(男人:<94厘米;女性:<80厘米)相比,大幅增加的腰围(男性:≥102厘米;女性:≥88厘米)的风险比为1.30(95% CI:1.12-1.51)。由于超重和肥胖(BMI≥25 kg / m2)引起的AVS病例所占的比例为10.8%(95% CI:5.2 -16.4%)。

由此可见,肥胖与AVS的风险增加有关。如果保持健康的身体质量指数,那么大部分AVS病例可能会被预防

原始出处
Susanna C. Larsson, Alicja Wolk, Niclas Hakansson, et al. Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies. EUR HEART J. 2017 July.

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    2017-07-29 虈亣靌

    厉害厉害……学习了

    0

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    2017-07-28 大爰

    学习了谢谢分享!!

    0

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    2017-07-27 zhaojie88
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    2017-07-27 slcumt
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    2017-07-27 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

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