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Ann Surg:非心脏手术是否会发生心肌损伤呢?

2017-05-12 MedSci MedSci原创

非心脏手术(MINS)后,MINS与患者30天死亡率独立相关。但是,目前关于MINS在血管外科手术患者中的特征和预后意义尚不清楚。近期,一项发表在杂志Ann Surg上的研究旨在确定与血管外科手术患者进行MINS后心肌损伤相关的预后相关性、临床特征和30天结局。此项研究是一项国际前瞻性队列研究,共有15,102例年龄大于等于45岁的非心脏手术患者入组。其中502例患者进行了血管手术。所有患者术前第

非心脏手术(MINS)后,MINS与患者30天死亡率独立相关。但是,目前关于MINS在血管外科手术患者中的特征和预后意义尚不清楚。


近期,一项发表在杂志Ann Surg上的研究旨在确定与血管外科手术患者进行MINS后心肌损伤相关的预后相关性、临床特征和30天结局。

此项研究是一项国际前瞻性队列研究,共有15,102例年龄大于等于45岁的非心脏手术患者入组。其中502例患者进行了血管手术。所有患者术前第3天均测量了第4代血浆肌钙蛋白T(TnT)浓度。MINS被定义为TnT浓度高于0.03ng / mL的继发性缺血。

此项研究的目的是确定(i)MINS在血管外科手术患者中是否具有预后的重要性,(ii)具有和不具有MINS的血管手术患者的临床特征,(iii)具有或不具有MINS的血管手术患者的30天结局,以及(iv)未经常规肌钙蛋白监测可能发生的未检测到的MINS的比例。

此项研究结果显示:血管外科手术患者MINS的发生率为19.1%(95%置信区间(CI),15.7%-22.6%)。存在MINS患者的30天全因死亡率为12.5%(95%CI 7.3%-20.6%),而无MINS患者为1.5%(95%CI为0.7%-3.2%)(P <0.001)。MINS与血管性病人的30天死亡率独立相关(优势比为9.48;95%CI为3.46〜25.96)。 

在心机缺血患者中(15.0%,95%CI,7.1-29.1)以及无心肌缺血患者中(12.2%; 95%CI,5.3-25.5,P = 0.76),MINS患者的30天死亡率相似。没有明显心肌缺血的MINS患者的血管外科手术患者比例为74.1%(95%CI,63.6-82.4)。

此项研究结果表明:血管手术后约1/5的患者出现MINS。MINS与患者的30天死亡率独立相关。大多数MINS患者是无症状的,如果没有常规的术后肌钙蛋白测量,将无法检测到。

原始出处:
Biccard BM, Scott DJA, et al. Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study. Ann Surg. 2017 May 8. doi: 10.1097/SLA.0000000000002290.

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    2017-05-17 jyzxjiangqin

    非手术可能致心肌损伤。

    0

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    2017-05-14 虈亣靌

    学习了,谢谢分享。

    0

  4. 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    2017-05-14 尹玉伟

    我觉得是肯定的……作为全身血液的动力……任何受伤都会对心脏有意者影响……研究很有意义!

    0

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    2017-05-14 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197796, encodeId=08ee19e79633, content=文章很好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun May 14 06:50:29 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197733, encodeId=eaff19e73351, content=是否有栓子形成?有呼吸爆发?, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun May 14 00:56:27 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197574, encodeId=e33c19e574d3, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat May 13 13:59:52 CST 2017, time=2017-05-13, status=1, ipAttribution=)]
    2017-05-14 惠映实验室

    是否有栓子形成?有呼吸爆发?

    0

  10. 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2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198094, encodeId=69af1980945f, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun May 14 20:59:30 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488272, encodeId=7d6b14882e264, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Sun May 14 11:27:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197926, encodeId=bce819e9262d, content=我觉得是肯定的……作为全身血液的动力……任何受伤都会对心脏有意者影响……研究很有意义!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Sun May 14 09:19:36 CST 2017, time=2017-05-14, status=1, 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    2017-05-13 天涯183

    非常好的文章,学习了,很受益

    0

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