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Circ: Cardiovascular Interventions:动脉粥样硬化的程度可以预测TAVR后急性肾损伤的发生、严重程度和恢复

2018-08-22 xiangting MedSci原创

肾上腺动脉粥样硬化负荷与TAVR后AKI的发生、严重程度和恢复相关。

急性肾损伤(AKI)是经导管主动脉瓣置换术(TAVR)的主要并发症。导管操作期间碎片引起的动脉栓塞被认为是导致AKI的潜在因素。这项研究调查了主动脉粥样斑块负荷对TAVR后AKI的影响,并评估了术前多层螺旋计算机断层扫描(MSCT)成像对这些患者AKI评估的潜能。

研究纳入278例接受TAVR的症状性重度主动脉瓣狭窄患者,分析了其术前多层螺旋CT图像。AKI被定义为血清肌酐绝对值增加≥0.3mg/dL。测量每个1-mm横断面图像中的主动脉血管和管腔面积。通过以下公式计算肾动脉上方(PAV肾动脉以上)和下方(PAV肾动脉以下)的粥样斑体积百分率:PAV = {Σ(血管面积-管腔面积)/Σ(血管面积)}×100。TAVR后有92例患者(33.1%)发生AKI。AKI与较高的上方PAV相关(30.4±8.2 vs 21.3±5.8%; P=0.02),但与下方PAV不相关(28.9±7.7 vs 25.8±6.1%; P=0.41)。更高的上方PAV与AKI严重程度直接相关(P=0.008),与从峰值到出院的血清肌酐恢复水平呈负相关(r=0.78; P=0.002)。多因素分析表明,肾动脉上方PAV是AKI的显著预测因子(P=0.02)。ROC曲线分析确定了肾动脉上方PAV>29.5%是预测AKI的最佳阈值。

肾上腺动脉粥样硬化负荷与TAVR后AKI的发生、严重程度和恢复相关。这项研究强调了术前使用多层螺旋CT评估主动脉粥样硬化对于识别AKI高危患者的意义。

原始出处:

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    2018-12-20 quxin068
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    2018-08-23 wxl882001

    学习一下

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