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J Korean Med Sci:肾功能不全对尿石症患者结石复发的影响

2020-03-01 不详 网络

本研究旨在评估肾小球滤过率(GFR)与尿结石形成成分之间的关系,并评估肾功能不全对初次结石形成者(SF)结石复发风险的影响。获得基线血清肌酐水平,并将肾功能不全定义为肌酐清除率≤60 mL / min(Cockroft-Gault)。选择肾功能正常的171 SF,倾向评分为1:1,与肾功能不全的171 SF相匹配。将尿代谢评估与肾功能进行比较。 结果显示,GFR与尿钙,尿酸和柠檬酸盐排泄呈正相关。

本研究旨在评估肾小球滤过率(GFR)与尿结石形成成分之间的关系,并评估肾功能不全对初次结石形成者(SF)结石复发风险的影响。

获得基线血清肌酐水平,并将肾功能不全定义为肌酐清除率≤60 mL / min(Cockroft-Gault)。选择肾功能正常的171 SF,倾向评分为1:1,与肾功能不全的171 SF相匹配。将尿代谢评估与肾功能进行比较。

结果显示,GFR与尿钙,尿酸和柠檬酸盐排泄呈正相关。肾功能不全的受试者的尿钙,尿酸和柠檬酸排泄明显低于肾功能正常的受试者,但尿量却没有。关于尿代谢异常,获得了相似的结果。肾功能不全的SF的草酸钙过饱和指数和结石复发率低于肾功能正常的SF。Kaplan-Meier曲线显示出相似的结果。

总之,GFR与SF中结石形成成分的尿排泄呈正相关。这一发现表明,肾功能不全不是结石复发的危险因素。

原始出处:

Ho Won Kang, Sung Phil Seo, et al., Effect of Renal Insufficiency on Stone Recurrence in Patients with Urolithiasis. J Korean Med Sci. 2014 Aug; 29(8): 1132–1137. doi: 10.3346/jkms.2014.29.8.1132

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