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2016 孕激素维持早期妊娠及防治流产的中国专家共识

2016-07-30 妇产科相关专家组(统称) 中华妇产科杂志.2016,51(7):481-483.

孕激素在妊娠早期具有维持蜕膜化子宫内膜、松弛子宫平滑肌、改善子宫血液供应以及免疫调节等重要作用,在临床上广泛应用于防治流产和辅助生育技术相关的孕激素补充,取得了良好的效果。鉴于目前黄体功能的判断没有准确、适当的方法,且临床上所应用的孕激素剂型和剂量存在差异,影响了药效的观察,至今尚缺乏循证医学证据,因而在具体疗效方面尚存在争议。为此,我们成立了由妇科内分泌学、产科学、生殖医学专家共同参与的孕激素维

中文标题:

2016 孕激素维持早期妊娠及防治流产的中国专家共识

发布日期:

2016-07-30

简要介绍:

孕激素在妊娠早期具有维持蜕膜化子宫内膜、松弛子宫平滑肌、改善子宫血液供应以及免疫调节等重要作用,在临床上广泛应用于防治流产和辅助生育技术相关的孕激素补充,取得了良好的效果。 

鉴于目前黄体功能的判断没有准确、适当的方法,且临床上所应用的孕激素剂型和剂量存在差异,影响了药效的观察,至今尚缺乏循证医学证据,因而在具体疗效方面尚存在争议。为此,我们成立了由妇科内分泌学、产科学、生殖医学专家共同参与的孕激素维持早期妊娠及防治流产共识的中国专家组,就孕激素应用的适应证、禁忌证和慎用情况及临床应用要点,专家们根据临床研究及诊疗经验,深入交流讨论,达成了本共识,旨在对妇科医师、产科医师以及生殖医学专科医师在孕激素用于维持早期妊娠、预防或治疗流产方面给出指导意见。 

一、孕激素应用的适应证孕激素应用的适应证包括:

1.早期先兆流产(孕12周前)。

2.晚期先兆流产(孕13~28周)。

3.复发性流产再次妊娠。

4.助孕周期。 

二、孕激素使用的禁忌证和慎用情况

1. 禁忌证:

(1)对药物制剂成分(黄体酮或任何其他赋形成分)过敏者;

(2)不明原因阴道流血;

(3)妊娠期或应用性激素时发生或加重的疾病(或症状)者,如严重瘙痒症、阻塞性黄疸、妊娠期疱疹、卟啉病和耳硬化症患者;

(4)异位妊娠、疑似妊娠滋养细胞疾病或者生殖系统之外的疾病引起的不明原因血hCG水平升高者;

(5)胚胎已死亡或者难免流产,若阴道流血持续增多,考虑流产不可避免者;

(6)脑膜瘤;

(7)其他:胎膜早破、胎儿畸形、绒毛膜羊膜炎等。 

2. 慎用的情况:主要包括以下方面:

(1)严重肝损伤、肾病或心脏病性水肿、高血压、脑血管意外的患者应慎用。

(2)自身免疫性疾病:研究表明,孕激素可以促进系统性红斑狼疮的发生,系统性红斑狼疮患者使用孕激素应慎重。而在其他自身免疫性疾病,包括类风湿性关节炎、多发性硬化、自身免疫性甲状腺疾病、干燥综合征、系统性硬化症等,缺乏明确的孕激素禁忌使用的依据。(3)血栓性疾病病史者,存在或疑似发生动静脉血栓的患者,既往有静脉炎、脑血管意外等病史的患者应慎用。


拓展指南:流产相关指南:

相关资料下载:
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class="MsoNormal">鉴于目前黄体功能的判断没有准确、适当的方法,且临床上所应用的孕激素剂型和剂量存在差异,影响了药效的观察,至今尚缺乏循证医学证据,因而在具体疗效方面尚存在争议。为此,我们成立了由妇科内分泌学、产科学、生殖医学专家共同参与的孕激素维持早期妊娠及防治流产共识的中国专家组,就孕激素应用的适应证、禁忌证和慎用情况及临床应用要点,专家们根据临床研究及诊疗经验,深入交流讨论,达成了本共识,旨在对妇科医师、产科医师以及生殖医学专科医师在孕激素用于维持早期妊娠、预防或治疗流产方面给出指导意见。<span style="font-size: 9pt;"> </span></p><p class="MsoNormal"><!--[if !supportLists]--><span style="font-weight: bold;">一、<!--[endif]-->孕激素应用的适应证孕激素应用的适应证包括:</span><o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->1.<!--[endif]-->早期先兆流产(孕12周前)。<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->2.<!--[endif]-->晚期先兆流产(孕13~28周)。<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->3.<!--[endif]-->复发性流产再次妊娠。<o:p></o:p></p><p class="MsoNormal">4.助孕周期。<span style="font-size: 9pt;"> </span></p><p class="MsoNormal"><!--[if !supportLists]--><span style="font-weight: bold;">二、<!--[endif]-->孕激素使用的禁忌证和慎用情况</span><o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->1. <!--[endif]-->禁忌证:<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(1)<!--[endif]-->对药物制剂成分(黄体酮或任何其他赋形成分)过敏者;<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(2)<!--[endif]-->不明原因阴道流血;<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(3)<!--[endif]-->妊娠期或应用性激素时发生或加重的疾病(或症状)者,如严重瘙痒症、阻塞性黄疸、妊娠期疱疹、卟啉病和耳硬化症患者;<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(4)<!--[endif]-->异位妊娠、疑似妊娠滋养细胞疾病或者生殖系统之外的疾病引起的不明原因血hCG水平升高者;<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(5)<!--[endif]-->胚胎已死亡或者难免流产,若阴道流血持续增多,考虑流产不可避免者;<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(6)<!--[endif]-->脑膜瘤;<o:p></o:p></p><p class="MsoNormal">(7)其他:胎膜早破、胎儿畸形、绒毛膜羊膜炎等。<span style="font-size: 9pt;"> </span></p><p class="MsoNormal"><!--[if !supportLists]-->2. <!--[endif]-->慎用的情况:主要包括以下方面:<o:p></o:p></p><p class="MsoNormal"><!--[if !supportLists]-->(1)<!--[endif]-->严重肝损伤、肾病或心脏病性水肿、高血压、脑血管意外的患者应慎用。<o:p></o:p></p><p class="MsoNormal">(2)自身免疫性疾病:研究表明,孕激素可以促进系统性红斑狼疮的发生,系统性红斑狼疮患者使用孕激素应慎重。而在其他自身免疫性疾病,包括类风湿性关节炎、多发性硬化、自身免疫性甲状腺疾病、干燥综合征、系统性硬化症等,缺乏明确的孕激素禁忌使用的依据。(3)血栓性疾病病史者,存在或疑似发生动静脉血栓的患者,既往有静脉炎、脑血管意外等病史的患者应慎用。<o:p></o:p></p> <br> 拓展指南:<strong>与<font color="red">流产</font>相关指南:</strong><br><ul><li><a href="//www.sandwebs.com/guideline/show_article.do?id=5110b1c001258837" title="2016 孕激素维持早期妊娠及防治流产的中国专家共识" target="_blank">2016 孕激素维持早期妊娠及防治流产的中国专家共识</a></li> <li><a href="//www.sandwebs.com/guideline/show_article.do?id=0e28d1c001216100" title="2016 SOGC临床实践指南:药物流产(No.332)" target="_blank">2016 SOGC临床实践指南:药物流产(No.332)</a></li> <li><a href="//www.sandwebs.com/guideline/show_article.do?id=ba63b1c00105e263" title="2014 ACOG 143号指南:孕早期流产医学管理" target="_blank">2014 ACOG 143号指南:孕早期流产医学管理</a></li> <li><a href="//www.sandwebs.com/guideline/show_article.do?id=1444f1c0010a2452" title="2014 WHO临床实践手册:安全流产" target="_blank">2014 WHO临床实践手册:安全流产</a></li> <li><a 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    2020-09-21 ms5000000097412993

    学习一下!非常感谢

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=887077, encodeId=ac3688e07771, content=学习一下!非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ed95417703, createdName=ms5000000097412993, createdTime=Mon Sep 21 13:35:33 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137792, encodeId=3a9613e79288, content=嗯!很全面, beContent=null, objectType=guider, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81091959532, createdName=1e131a34m86(暂无匿称), createdTime=Thu Sep 29 21:23:53 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122464, encodeId=3fcb122464e4, content=没有梅斯医学指导还真不知道这些,得好好学习呀, beContent=null, objectType=guider, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 11:24:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105164, encodeId=22c510516471, content=实用性感觉会不错的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcad1943078, createdName=1e0f7307m29(暂无匿称), createdTime=Fri Aug 26 23:51:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105163, encodeId=83861051630e, content=实用性感觉会不错的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcad1943078, createdName=1e0f7307m29(暂无匿称), createdTime=Fri Aug 26 23:49:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-09-29 1e131a34m86(暂无匿称)

    嗯!很全面

    0

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    2016-09-11 1e10c84am36(暂无匿称)

    没有梅斯医学指导还真不知道这些,得好好学习呀

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=887077, encodeId=ac3688e07771, content=学习一下!非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ed95417703, createdName=ms5000000097412993, createdTime=Mon Sep 21 13:35:33 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137792, encodeId=3a9613e79288, content=嗯!很全面, beContent=null, objectType=guider, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81091959532, createdName=1e131a34m86(暂无匿称), createdTime=Thu Sep 29 21:23:53 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122464, encodeId=3fcb122464e4, content=没有梅斯医学指导还真不知道这些,得好好学习呀, beContent=null, objectType=guider, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 11:24:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105164, encodeId=22c510516471, content=实用性感觉会不错的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcad1943078, createdName=1e0f7307m29(暂无匿称), createdTime=Fri Aug 26 23:51:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105163, encodeId=83861051630e, content=实用性感觉会不错的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcad1943078, createdName=1e0f7307m29(暂无匿称), createdTime=Fri Aug 26 23:49:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-08-26 1e0f7307m29(暂无匿称)

    实用性感觉会不错的

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=887077, encodeId=ac3688e07771, content=学习一下!非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ed95417703, createdName=ms5000000097412993, createdTime=Mon Sep 21 13:35:33 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137792, encodeId=3a9613e79288, content=嗯!很全面, beContent=null, objectType=guider, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81091959532, createdName=1e131a34m86(暂无匿称), createdTime=Thu Sep 29 21:23:53 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122464, encodeId=3fcb122464e4, content=没有梅斯医学指导还真不知道这些,得好好学习呀, beContent=null, objectType=guider, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 11:24:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105164, encodeId=22c510516471, content=实用性感觉会不错的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcad1943078, createdName=1e0f7307m29(暂无匿称), createdTime=Fri Aug 26 23:51:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=105163, encodeId=83861051630e, content=实用性感觉会不错的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fcad1943078, createdName=1e0f7307m29(暂无匿称), createdTime=Fri Aug 26 23:49:00 CST 2016, time=2016-08-26, status=1, ipAttribution=)]
    2016-08-26 1e0f7307m29(暂无匿称)

    实用性感觉会不错的

    0

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