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BMJ:鸡蛋摄入量与心血管疾病风险

2020-03-05 xing.T MedSci原创

由此可见,来自这三个队列和最新的荟萃分析结果表明,适量食用鸡蛋(每天最多一个鸡蛋)与总体心血管疾病风险无关,而与亚洲人群较低的潜在心血管疾病风险有关。

近日,顶级杂志BMJ上发表了一篇研究文章,该研究旨在评估男性和女性鸡蛋摄入量与心血管疾病风险之间的关联,并对前瞻性队列研究进行荟萃分析。

该研究以护士健康研究(NHS,1980-2012)、NHS II(1991-2013)、卫生专业人员随访研究(HPFS,1986-2012)为基础。队列分析纳入了83349名来自NHS的女性、90214名来自NHS II的女性和42055名来自HPFS的男性,他们在基线时没有心血管疾病、2型糖尿病和癌症。该研究的主要结局指标为新发性心血管疾病,包括非致命性心肌梗塞、致命性冠心病和卒中

在长达32年的随访(>554万人次每年)中,在这三个队列中共确诊了14806名患心血管疾病的参与者。鸡蛋摄入量较高的参与者的体重指数较高,接受他汀类药物治疗的可能性较小,并且食用了更多的红肉。大多数人每周摄入一到五个鸡蛋。在汇总的多变量分析中,调整了与鸡蛋摄入量相关的生活方式和饮食因素后,每天至少摄入一个鸡蛋与发生心血管疾病的风险无关(每天至少一个鸡蛋于每月少于一个鸡蛋的风险比为0.93,95%置信区间为0.82至1.05)。在更新的前瞻性队列研究荟萃分析(33项风险估计,1720108名参与者,139195例心血管疾病事件)中,每天增加一个鸡蛋与心血管疾病风险无关(合并相对风险为0.98,95%置信度区间为0.93至1.03,I2=62.3%)。对于冠心病(21项风险评估,1411261名参与者,59713例冠心病事件;0.96,0.91至1.03,I2=38.2%)和卒中的结果相似(22项风险估计,1059315名参与者,53617例卒中事件;0.99,0.91至1.07,I2=71.5%)。在按地理位置进行分层的分析中(相互作用的P=0.07),在美国(1.01,0.96至1.06,I2=30.8%)或欧洲(1.05,0.92至1.19,I2=64.7%)人群中,未发现鸡蛋摄入量与心血管疾病风险之间存在关联,但在亚洲队列研究中却发现了负相关(0.92,0.85至0.99,I2=44.8%)。

由此可见,来自这三个队列和最新的荟萃分析结果表明,适量食用鸡蛋(每天最多一个鸡蛋)与总体心血管疾病风险无关,而与亚洲人群较低的潜在心血管疾病风险有关。

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    2020-10-22 lmm397
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    2020-11-01 gaoxiaoe
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