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J Thromb Haemost:特发性血小板减少性紫癜与心血管疾病之间的相关性分析!

2018-01-04 xing.T MedSci原创

由此可见,ITP患者发生CVD的风险增加,接受脾切除的ITP患者发生CVD的风险甚至进一步增加。

特发性血小板减少性紫癜(ITP)的典型特征是血小板计数短暂或持续下降。 ITP人群死亡率高于一般人群,可能与心血管疾病(CVD)增加有关。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在评估ITP与CVD之间相关性的强度,第二个目的是评估脾切除对CVD的影响。

研究人员使用来自于6591名ITP患者和24275名随机匹配对照者(按照年龄、性别、体重指数和吸烟状态以1:4的比率匹配)的临床代码数据进行基于人群的回顾性开放队列研究。该研究的主要结局为心血管疾病的风险,包括缺血性心脏病、卒中、短暂性脑缺血发作和心力衰竭。研究人员使用泊松回归计算调整后的发生率比率。

在6年的中位观察期间,392例(5.9%)ITP患者和1114例(4.5%)对照者被诊断为CVD。在ITP队列中发生CVD的风险增加(调整后的IRR为1.38;95%可信区间为1.23-1.55),即使在仅包括ITP病例的敏感性分析之后仍然保持稳健。研究结果显示接受脾切除术的患者与没有接受脾切除的ITP患者相比,发生CVD的风险进一步增加(调整后的IRR为1.69;95%可信区间为1.22-2.34)。

由此可见,ITP患者发生CVD的风险增加,接受脾切除的ITP患者发生CVD的风险甚至进一步增加。

原始出处:

Joht Singh Chandan.et al. The Association between Idiopathic Thrombocytopenic Purpura and Cardiovascular Disease: a retrospective cohort study.Journal of Thrombosis and Haemostasis.2018.http://onlinelibrary.wiley.com/doi/10.1111/jth.13940/full

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    2018-10-31 changfy
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  5. 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  6. 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  7. 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createdName=bluefate124, createdTime=Sat Jan 06 01:14:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498348, encodeId=852314983487d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Jan 06 01:14:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523578, encodeId=425515235e803, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, 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    2018-01-06 bluefate124
  8. 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