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27岁小伙子首次看病就查出尿毒症,难道尿毒症前没有症状吗?

2017-09-20 李青 天津市泰达医院

有一天上午我就要下班时,一个27岁的小伙子过来说神经科的医生让他过来找我。原来他血压高,头晕,先看的神经科,做了一个脑CT没有发现问题,于是神经科医生推荐来看我的门诊。

有一天上午我就要下班时,一个27岁的小伙子过来说神经科的医生让他过来找我。原来他血压高,头晕,先看的神经科,做了一个脑CT没有发现问题,于是神经科医生推荐来看我的门诊。

我给他量血压220/130mmHg,除了脑CT外没有别的任何检查。我简单问病史,他说他高血压1年(后来回忆说已经2年了),最近尿中泡沫多。我给他急查尿常规,尿蛋白3+,镜下血尿。初步诊断为慢性肾小球肾炎,肾性高血压。因他血压太高,我让他住院检查治疗,他说他马上结婚了,没有时间,于是就走了。

我给他开的其他检查他过了几天才来抽血,结果出来后发现,血色素69g/L(正常130-160g/L),血肌酐1755μmol/L。根据诊断标准,血肌酐≥707μmol/L就是尿毒症,而且根据较重的肾性贫血分析,他的肾衰竭应该是慢性而非急性。追问病史,他2年前就发现高血压,但没有进行任何检查治疗;半个月前开始就总是恶心,也没有到医院就医。

他刚领了结婚证还没有办婚礼。他告诉我们,他要去北京治疗。

他以前自认为身体很好,从没有做过体检,婚前体检自然也没有做。他才27岁,第一次就医就诊断为尿毒症,难道尿毒症前没有症状吗?

尿毒症不是一个疾病,而是所有慢性肾脏病的晚期状态。一般来说,从发生肾脏病到尿毒症有一个漫长的过程,当然有些肾脏病的进展很快,但也有一定的病程,期间总会出现一些症状。慢性肾脏病常见的迹象(症状)有:

1、蛋白尿:肾脏受损后,血液中的蛋白质就会漏到尿中形成蛋白尿,尿常规检查为尿蛋白阳性,严重程度从1+~4+,当然还可以定量检查。大量的蛋白尿会出现尿中泡沫增多,久不消散,细心的患者自己就能发现。蛋白尿是慢性肾脏病早期而确定的证据,几乎所有的肾脏病都会出现尿蛋白阳性。所以,一次比血常规还简单的尿常规检查就能发现肾脏病。

2、血尿:尿液离心后沉渣做显微镜检查,红细胞数每高倍视野≥3个就诊断为血尿,这是镜下血尿。严重的血尿呈鲜红色、酱油色或者洗肉水样,称肉眼血尿。许多肾脏病都有血尿。

3、高血压:肾脏缺血或者受损后就会分泌一种物质叫肾素,后者通过一系列的病理生理过程引起高血压,称肾性高血压。绝大部分肾脏病人和几乎所有的尿毒症病人都会出现高血压,而且血压都很高,就像这位患者。

4、水肿:严重的肾脏病由于钠水潴留或者丢失蛋白太多引起的低蛋白血症还会出现水肿。前者以眼睑及面部水肿为主,后者以下肢水肿为主。

5、血肌酐升高:肾功能受损后,肌酐等代谢废物蓄积,出现血肌酐升高,同时尿素氮、尿酸、血钾等也升高。血肌酐升高,就意味着肾功能受损,肾脏病严重到一定的程度。

6、贫血:肾功能损害到一定等程度后,肾脏分泌的促红素分泌不足,就会出现贫血。急性肾衰竭不会出现贫血,贫血是慢性肾功能衰竭的标志。一般来说,贫血的严重程度与肾衰的严重程度相一致。

7、肾性骨病:肾衰后,肾脏不能活化皮肤经紫外线照射后产生的维生素D,活性维生素D缺乏。主要表现严重的骨质疏松,病理性骨折(很小的外力就引起骨折),还会表现高磷血症和转移性钙化(血管钙化)等。

8、其他:代谢废物刺激胃肠道粘膜导致恶心、呕吐等胃肠道症状;皮肤代谢障碍还会出现皮肤干燥、脱屑等。

反过来再说这个小伙子:

1、如果他每年体检,一次尿常规就能告诉他肾脏出了问题,但他从不查体;

2、一般来说,原发性高血压大多40岁后发病,所以对40岁之前出现的高血压首先考虑是其他疾病引起的继发性高血压,一定要围绕肾脏、肾上腺和肾血管等进行检查。2年前他就发现高血压,但未引起重视。分析他那个时候已经出现了肾脏病,如果那时他检查治疗了,也许走不到这一步。

3、半个月前反复恶心,已经是尿毒症的症状了,也没有引起他的重视;婚前检查,肯定要查血尿常规和肝肾功能等,一查便知,可惜,他连婚前检查的过场都没走。当然,这个时候即使发现了也已经是尿毒症了。

综上所述,不是发生尿毒症前没有症状,而是他忽略了所有的疾病信号,也失去了早期治疗的机会。

从他不参加单位的体检,到此次就医的表现来看,他对疾病治疗的依从性很差,不听医生的活,不配合医生的治疗。临床工作中我们也发现,许多尿毒症病人的依从性都很差,想一想也是,听话并积极配合治疗的患者,也许走不到尿毒症这一步。

他这种程度,只能血液透析或者腹膜透析了,如果他有条件,也可以肾移植。

此外,鼓吹体检无用的人必遭天谴。定期体检,许多疾病可以早发现、早治疗。商城、酒店、车站的消防预警装置可能没有使用的机会,但你不能说这些设施是无用的。

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    2017-09-22 tcm99hq
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    2017-09-21 榄枷檬

    谢谢分享

    0

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    2017-09-21 187清风

    怎么会没症状.不重视而已

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    2017-09-20 131****1460

    学习了受益匪浅

    0

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    2017-09-20 1e11aec8m53(暂无匿称)

    讳疾忌医

    0

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    2017-09-20 衣带渐宽

    学习

    0

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    2017-09-20 1e0f8808m18(暂无匿称)

    违疾忌医.误延疾病的诊治最佳时机.

    0

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    2017-09-20 楠博One

    疾病突如其来

    0

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    2017-09-20 营养医师

    真是人有旦夕祸福.健康最重要了

    0

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    2017-09-20 吴晶晶

    经常遇到这种...查了才知道是肾衰

    0

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一不小心,糖尿病变成了尿毒症!

随着糖尿病病人数量的与日俱增,糖尿病出现的合并症也越来越引起大家的重视,如心脑血管疾病、糖尿病足、糖尿病视网膜病变、糖尿病胃肠病变、糖尿病神经病变等等。其中最重要也是比较常见的并发症就是糖尿病肾病了。国外终末期肾衰尿毒症的病人有50%的原发病为糖尿病,我国和一些发展中国家还是以肾小球肾炎为首要的原发病。但是随着糖尿病病人的增多,目前糖尿病肾病造成的肾衰已经达到终末期肾衰病人的30%之多,而且还有继

SCI REP:血清铁调素可能是一种新的尿毒症毒素,可能与促红细胞生成素抵抗有关!

这些研究结果表明血清铁调素可能是尿毒症毒素中的一种,并且在促红细胞生成素耐药中发挥着重要作用。然而,进一步进行前瞻性研究以确认这些研究结果是很有必要的。

Atherosclerosis:长期血液透析的尿毒症患者,血清总胆红素与死亡率的关系

研究表明,高水平的胆红素与长期血液透析的尿毒症患者的死亡率有关,仍然需要进一步研究非结合胆红素或结合胆红素对血液透析患者的不同作用。

Kidney Int:血液透析的频率和时间增加是否有效?

常规的每周三次治疗与那些接受中心血液透析的患者中每周进行更频繁更长时间的治疗相比较,效果如何?近期,频繁血液透析网络将这两者进行了比较研究。此项历经一年的研究结果显示强化治疗对左心室质量、血压和磷酸盐控制有益处,但对身体及认知表现没有影响。此项研究比较了来自53名接受每周三次中心血液透析(平均每周时间为10.9小时)的试验患者和30名接受每周六次的中心血液透析(平均每周14.6小时)的试验患者的储

慢性肾盂肾炎、尿毒症竟误诊为再生障碍性贫血!

女70岁,因头晕,无力,伴有恶心,呕吐一个月就诊。慢性肾盂肾炎、尿毒症竟误诊为再生障碍性贫血,误诊原因是什么?有哪些经验教训值得学习?

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