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J Alzheimers Dis: AD患者‪发生心血管事件30天后死亡率

2015-09-26 phylis译 MedSci原创

背景和目的:患有阿尔茨海默的患者(AD)并未得到标准的治疗。研究人员研究了AD患者或非AD患者缺血性卒中,出血性卒中或者心肌梗死后30年的死亡率。方法:选取2005-2012年间,芬兰社区居民诊断为AD的患者(n=73005)以及1-4配对的对照组人群/AD影响的人群(n=215449)进行配对研究。从国家医院出院记录中获得缺血性卒中(n=16419;死亡:2748);出血性卒中(n=3570;死

背景和目的:通常患有阿尔茨海默的患者(AD)很难得到标准的治疗。研究人员研究了AD患者或非AD患者缺血性卒中,出血性卒中或者心肌梗死后30天的死亡率。

方法:选取2005-2012年间,芬兰社区居民诊断为AD的患者(n=73005)以及1-4配对的对照组人群/AD影响的人群(n=215449)进行配对研究。从国家医院出院记录中获得缺血性卒中(n=16419;死亡:2748);出血性卒中(n=3570;死亡:1224)以及心肌梗死(n=15304;死亡:3804)后的30天死亡率。主要分析首次发生事件。

结果:AD患者的缺血性卒中(校正HR=1.36,95%CI:1.24 1.49),出血性卒中(校正HR=1.11 95%CI:0.98 1.25)或心肌梗死(校正HR=1.40 95%CI:1.30 1.51)后30天死亡率轻度升高。这种相关性不受年龄,性别或共发病的影响,并且先前存在缺血性卒中或梗死的患者也存在此种相关性。缺血性卒中,出血性卒中以及心肌梗死后30天死亡率的绝对风险分别为4.9% (95% CI 3.3,6.5), 3.3% (95% CI - 1.6,8.2)以及 7.5% (95% CI 5.0,10.0)。

结论:尽管AD患者30天死亡率相对较高,但绝对差异较小,AD患者的急性治疗的效果不是很显著。死亡率轻度升高不能由共发病解释,但可反映一般高死亡率AD患者或严重认知功能损害患者的治疗实践。

原文出处:

Heiskanen J, Hartikainen S, Roine RP, Tolppanen AM. 30-Day Mortality after Cardiovascular Events in Persons with or without Alzheimer's Disease.J Alzheimers Dis. 2015 Aug 28


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    2015-12-14 仁心济世
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    2016-07-11 smlt2008
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