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DIABETOLOGIA:吸烟对1型糖尿病患者冠心病,心力衰竭和中风风险的剂量依赖性影响如何?

2018-12-02 MedSci MedSci原创

本研究的目的是评估吸烟对1型糖尿病患者冠心病,心力衰竭和中风风险的潜在剂量依赖性影响。该研究包括4506名参与芬兰糖尿病肾病(FinnDiane)研究的1型糖尿病患者。吸烟强度按每天每包计算,累计吸烟按包每年计算。采用Cox回归分析评估随访期间发生冠心病,心力衰竭或中风的风险。 结果显示,在校正年龄,性别,HbA 1c,高血压,糖尿病持续时间和BMI 后,每天一包吸烟量会显著增加吸烟者与不吸

本研究的目的是评估吸烟对1糖尿病患者冠心病,心力衰竭和中风风险的潜在剂量依赖性影响。该研究包括4506名参与芬兰糖尿病肾病(FinnDiane)研究的1糖尿病患者。吸烟强度按每天每包计算,累计吸烟按包每年计算。采用Cox回归分析评估随访期间发生冠心病,心力衰竭或中风的风险。

结果显示,在校正年龄,性别,HbA 1c高血压,糖尿病持续时间和BMI 后,每天一包吸烟量会显著增加吸烟者与不吸烟者相比患CHD的风险(HR 1.45 [95CI 1.15,1.84])。以前吸烟者患冠心病的风险与从不吸烟者的风险相似。当前吸烟者每天每包吸烟的风险为1.4395CI 1.03,1.97),以前吸烟者为1.3795CI 1.05,1.77),而卒中发生的风险分别为1.7095CI)分别为1.26,2.29)和1.4995CI 1.14,1.93)。然而,在进一步校正脂质后,当前和以前吸烟者心力衰竭风险的差异不再显著。累积吸烟数据与吸烟强度数据相似。

1型糖尿病患者的吸烟与血管疾病之间存在剂量依赖关系。特别是在男性中,即使戒烟后卒中风险仍然很高,并且在当前和以前的吸烟者中,独立于其他危险因素,分险也会升高。

原始出处:

Maija FeodoroffValma HarjutsaloCarol Forsblom, Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1638886, encodeId=8a6e163888667, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Feb 13 02:42:00 CST 2019, time=2019-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968272, encodeId=d99d19682e205, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Wed Feb 27 22:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739702, encodeId=08041e397027f, content=<a href='/topic/show?id=ff0c2262459' target=_blank style='color:#2F92EE;'>#中风风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22624, encryptionId=ff0c2262459, topicName=中风风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9ba34554146, createdName=1249898am26暂无昵称, createdTime=Sat Apr 20 07:42:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760918, encodeId=609a1e60918ec, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Mar 24 08:42:00 CST 2019, time=2019-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474656, encodeId=b27514e465621, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Dec 04 12:42:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042085, encodeId=86161042085ea, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Dec 03 00:42:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045819, encodeId=b65a1045819f5, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Dec 03 00:42:00 CST 2018, time=2018-12-03, status=1, ipAttribution=)]
    2018-12-03 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-12-03 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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