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Clin Exp Rheumatol:中轴型脊柱关节炎患者颈动脉超声后被重新归类为超高危心血管风险

2020-04-12 xiangting MedSci原创

与对照组相比,颈动脉超声后axSpA患者更容易被重新归类为超高风险类别。传统心血管危险因素对患者与对照组重新分类的影响是不同的。

被定义为存在颈动脉斑块的亚临床型动脉粥样硬化在中轴型脊柱关节炎(axSpA)患者中比在健康个体中更常见。这项研究旨在确定颈动脉超声检查后,axSpA患者是否比对照组更多地被归类为超高危心血管风险,并且是否与疾病特征有关。

研究纳入根据ASAS标准诊断的343名axSpA患者和177名对照。评估患者和对照的疾病特征和系统性冠脉风险评估(SCORE)。通过颈动脉超声确定是否存在斑块和内膜中层厚度(cIMT)。进行多因素回归分析确定患者与对照之间重新分类发生率的差异,以及与axSpA重新分类相关的因素。

与对照组相比,axSpA患者颈动脉斑块(36%vs. 25%,p=0.010)和cIMT增厚(0.641±0.121 vs.0.602±0.115mm,p=0.001)更常见。axSpA患者被重新分类为高危类别的比例更高(34%vs.25%,p=0.037)。多因素分析后,年龄(axSpA患者β系数2.74 [95%CI 1.34-5.62]vs.β系数0.63(95%CI 0.40-0.99),p相互作用=0.001)和血清LDL-胆固醇(β系数 1.03[95%CI 1.02-1.04] vs. β系数1.00[0.99–1.01],p相互作用=0.029)对对照组重新分类的影响更大。尽管axSpA重新分类与ASDAS-CRP、BASFI和BASMI评分较高相关,但调整了心血管危险因素后,这些相关性不再存在。

与对照组相比,颈动脉超声后axSpA患者更容易被重新归类为超高风险类别。传统心血管危险因素对患者与对照组重新分类的影响是不同的。

原始出处:

J.Rueda-Gotor.Reclassification into very-high cardiovascular risk after carotid ultrasound in patients with axial spondyloarthritis. Clin Exp Rheumatol. February 2020.

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    2020-04-14 lmm397
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