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Cancer:乳腺癌与血统有关,非裔发病率更高

2016-09-27 周奕 中国网

Barbara Haley医生(左)和 Roshni Rao医生。(来源:德州大学西南医学中心)据美国《每日科学》报道,最新研究显示,线粒体基因测试可揭秘血统与特定类型乳腺癌发病率之间的关系。德州大学西南医学中心的癌症研究员通过分析一组三阴性乳腺癌患者的线粒体DNA后发现,有13%的患者并不了解他们的血统对癌症发病率有何影响。本研究第一作者,乳腺外科中心主任Roshni Rao医生说:“我们在92


Barbara Haley医生(左)和 Roshni Rao医生。(来源:德州大学西南医学中心)

据美国《每日科学》报道,最新研究显示,线粒体基因测试可揭秘血统与特定类型乳腺癌发病率之间的关系。德州大学西南医学中心的癌症研究员通过分析一组三阴性乳腺癌患者的线粒体DNA后发现,有13%的患者并不了解他们的血统对癌症发病率有何影响。

本研究第一作者,乳腺外科中心主任Roshni Rao医生说:“我们在92个患者中找到12个存在认知偏差的,这是一个相当大的数量。”

她还表示:“一些认为自己是拉美裔的患者实际上是非裔。一个拉美裔女性患者被发现是德系犹太人。非裔和一些德系犹太人都有较高的三阴乳腺癌患癌风险。”

三阴乳腺癌特指雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体2(HER-2)均阴性的乳腺癌,占乳腺癌患者总数的15~20%左右。该型乳腺癌侵袭性强,治疗难度大,癌转移发生率和死亡率均高于非三阴乳腺癌。标准乳癌治疗药物如他莫昔芬、芳香化酶抑制剂、曲妥珠单抗等对此类型乳腺癌无效。

“这项研究首次为自称是非裔、高加索人和拉美裔的三阴乳腺癌患者做线粒体基因测试,试图找到意想不到的线粒体DNA信息。”本研究资深作者,内科教授Barbara Haley医生说,“据估计,10~30%的美国人不知道他们有混合血统。这在其它癌症的研究领域也有潜在的帮助,我们往往发现发病率上的种族差异却不知道其原因。”

三阴乳腺癌患者往往更年轻,且多为非裔或拉美裔。传统的乳腺X线摄影检查主要针对50岁以上的女性,因而较难检测出此类患者。

Rao医生说:“如果知道自己的血统,就有机会更早地接受检查。”

研究人员让包括31名非裔、31名高加索人和30名拉美裔在内的三阴乳腺癌患者接受一个简单的检查,用医用棉签采集脸颊细胞,并从中分离出线粒体DNA进行比较。线粒体DNA与核DNA不同,通过母系遗传,因此不会发生改变和混合。研究人员能利用线粒体DNA追踪数代人的血缘脉络。

在30名拉美裔患者中,8名有乳腺癌家族病史。这预示进一步的基因测试有望成为检测高危人群的重要步骤。

此外,一项出人意料的结果显示,有尼日利亚、喀麦隆和塞拉利昂血统的人士患三阴乳腺癌的风险最高。这意味着特定非洲国家血统往往伴随着较高的发病率。

原始出处:

Rao R1, Rivers A1, Rahimi A2, Wooldridge R1, Rao M1, Leitch M1, Euhus D3, Haley BB4.Genetic Ancestry using Mitochondrial DNA in patients with Triple-negative breast cancer (GAMiT study).Cancer. 2016 Sep 1.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1823294, encodeId=5ef0182329496, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 19 17:36:00 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136844, encodeId=0d6e136844ca, content=样本量是不是还是太小了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Wed Sep 28 08:37:06 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136605, encodeId=63941366056d, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:57 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136604, encodeId=982313660405, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:52 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136434, encodeId=5c19136434af, content=学习啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 20:08:23 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1823294, encodeId=5ef0182329496, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 19 17:36:00 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136844, encodeId=0d6e136844ca, content=样本量是不是还是太小了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Wed Sep 28 08:37:06 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136605, encodeId=63941366056d, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:57 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136604, encodeId=982313660405, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:52 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136434, encodeId=5c19136434af, content=学习啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 20:08:23 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-09-28 llaq

    样本量是不是还是太小了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1823294, encodeId=5ef0182329496, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 19 17:36:00 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136844, encodeId=0d6e136844ca, content=样本量是不是还是太小了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Wed Sep 28 08:37:06 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136605, encodeId=63941366056d, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:57 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136604, encodeId=982313660405, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:52 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136434, encodeId=5c19136434af, content=学习啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 20:08:23 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-09-27 知难而进

    继续关注!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1823294, encodeId=5ef0182329496, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 19 17:36:00 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136844, encodeId=0d6e136844ca, content=样本量是不是还是太小了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Wed Sep 28 08:37:06 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136605, encodeId=63941366056d, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:57 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136604, encodeId=982313660405, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:52 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136434, encodeId=5c19136434af, content=学习啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 20:08:23 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-09-27 知难而进

    谢谢分享!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1823294, encodeId=5ef0182329496, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 19 17:36:00 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136844, encodeId=0d6e136844ca, content=样本量是不是还是太小了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Wed Sep 28 08:37:06 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136605, encodeId=63941366056d, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:57 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136604, encodeId=982313660405, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Sep 27 22:15:52 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136434, encodeId=5c19136434af, content=学习啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Sep 27 20:08:23 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-09-27 医路开来

    学习啦,,,

    0

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