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JACC:肺功能的下降会增加心血管疾病风险

2018-08-29 MedSci MedSci原创

肺功能不全会增加心血管疾病(CVD)的发生风险。本研究的目的旨在评估肺功能的纵向下降是否与心衰、冠心病和卒中的发生相关。本研究纳入了ARIC 临床研究中的10351名无CVD的参与者,平均年龄为54 ± 6岁,女性占56%,白种人占81%。快速肺功能下降定义为1s用力呼气量(FEV1)或用力肺活量(FVC)下降的最大四分位数(n=2585)。经过平均17 ± 6年时间的随访,心衰的发生率为14%,

肺功能不全会增加血管疾病(CVD)的发生风险。本研究的目的旨在评估肺功能的纵向下降是否与心衰、冠心病和卒中的发生相关。

本研究纳入了ARIC 临床研究中的10351名无CVD的参与者,平均年龄为54 ± 6岁,女性占56%,白种人占81%。快速肺功能下降定义为1s用力呼气量(FEV1)或用力肺活量(FVC)下降的最大四分位数(n=2585)。经过平均17 ± 6年时间的随访,心衰的发生率为14%,冠心病为11%,卒中为6%,复合事件的发生率为24%。FEV1和FVC的快速下降均会增加心衰的发生风险([HR]: 1.17; 95% [CI]: 1.04 - 1.33; p = 0.010; HR: 1.27; 95% CI: 1.12 - 1.44; p < 0.001),其中FEV1的快速下降与患者的第一年预后相关性最强(HR: 4.22; 95% CI: 1.34 - 13.26; p = 0.01)。另外,FEV1的快速下降与卒中的发生也相关(HR: 1.25; 95% CI: 1.04 - 1.50; p = 0.015)。

研究结果显示,肺功能的快速下降会增加血管疾病的发生风险,尤其是心衰的发生风险。

原始出处:

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    2019-04-01 hbwxf
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    2018-08-29 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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