Front Aging Neurosci：脑脊液和血清中miRNA的水平可预测术后谵妄的发生相关

2017-08-08 MedSci MedSci原创

术后谵妄是术后常见并发症，其发生与患者预后不良有关。POD发生的病理生理机制尚不清楚，但是确定其发生的危险因素对术后预后却十分重要。本研究旨在探究术前脑脊液（CSF）和血清中miR-146a、miR-125b及miR-181c与POD的发生及严重程度之间的关系。研究纳入了40名65岁以上行腰麻下全髋/膝关节置换术的老年患者。术前使用简易精神状态检查评估患者基线时期的认知功能。每名患者在术后第一天和

术后谵妄是术后常见并发症，其发生与患者预后不良有关。POD发生的病理生理机制尚不清楚，但是确定其发生的危险因素对术后预后却十分重要。本研究旨在探究术前脑脊液（CSF）和血清中miR-146a、miR-125b及miR-181c与POD的发生及严重程度之间的关系。

研究纳入了40名65岁以上行腰麻下全髋/膝关节置换术的老年患者。术前使用简易精神状态检查评估患者基线时期的认知功能。每名患者在术后第一天和第二天接受了采访。使用谵妄评定方法确诊谵妄，并使用谵妄评定量表（MDAS）评估谵妄的严重程度。使用实时定量PCR（qRT-PCR）检测术前血清和CSF中miR的水平。

结果，27.5%的患者（11/40）确诊为POD。这些患者中术后CSF中miR-146a和miR-181c的水平升高，血清中miR-146a的水平降低，而发生或未发生POD的患者其血清或CSF中miR-125b的水平并无差别。谵妄患者miR-146a和miR-181c的脑脊液/血清比值水平较非谵妄患者高。较低的CSF miR-146a及脑脊液/血清miR-146a比值均与较轻的POD相关，由MDAS得分较低可以看出。

总之，该研究表明，术前血清和脑脊液中miR-146a和miR-181c水平的降低与POD的发生及其严重程度相关。这些miRNA可能参与了POD的病理生理过程，有待进一步调查研究。

原始出处：

Rui Dong, Lingling Sun, et al., NeurimmiRs and Postoperative Delirium in Elderly Patients Undergoing Total Hip/Knee Replacement: A Pilot Study. Front Aging Neurosci. 2017; 9: 200. Published online 2017 Jun 23. doi: 10.3389/fnagi.2017.00200.

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2019-07-01 小微940490

mark

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2017-08-31 smallant2002

#miR#

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2017-08-10 sunmin0219

#术后谵妄#

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2017-08-10 Homburg

#miRNA#

48 0
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2017-08-10 lsndxfj

#ROS#

48 0
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2017-08-09 明天会更好！

谢谢分享，学习了！

100 0
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2017-08-08 明崖

学习了，期待进一步了解

91 0
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2017-08-08 1e0c8d13m57(暂无匿称)

好文章

75 0
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2017-08-08 Y—xianghai

学习了新知识

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