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JACC:不同口服抗凝药物引起心梗风险的研究

2018-06-27 MedSci MedSci原创

目前,关于直接口服抗凝药物(DOAC)和维生素K抗凝药物(VKA)在预防心梗中的作用尚存在争议。本研究的目的旨在评估房颤患者服用阿哌沙班、达比加群酯、利伐沙班和VKA与心梗发生的相关性。本研究纳入了31739名房颤患者(平均年龄74岁,男性占53%),服用VKA治疗患者的1年标准化心梗发生风险为1.6%(95% [CI]: 1.3 - 1.8),阿哌沙班是1.2% (95% CI: 0.9 - 1

目前,关于直接口服抗凝药物(DOAC)和维生素K抗凝药物(VKA)在预防心梗中的作用尚存在争议。本研究的目的旨在评估房颤患者服用阿哌沙班、达比加群酯、利伐沙班和VKA与心梗发生的相关性。

本研究纳入了31739名房颤患者(平均年龄74岁,男性占53%),服用VKA治疗患者的1年标准化心梗发生风险为1.6%(95% [CI]: 1.3 - 1.8),阿哌沙班是1.2% (95% CI: 0.9 - 1.4),达比加群酯是1.2% (95% CI: 1.0 - 1.5),利伐沙班是1.1% (95% CI: 0.8 - 1.3)。在服用DOAC的患者中,1年标准化心梗发生风险无明显差异,而服用DOAC的患者的发病风险均低于服用VKA的患者。

本研究结果显示,心梗发生风险在各直接口服抗凝药物之间无明显差异,但服用DOAC发生心梗的风险要明显低于服用维生素K抗凝药物患者。

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    2018-08-03 hbwxf
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