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AJG:合并有精神症状的慢性胰腺炎患者其疼痛及生活质量均会明显恶化

2020-12-27 MedSci原创 MedSci原创

慢性胰腺炎(CP)是一种使人痛不欲生的胰腺疾病,它主要的症状是腹痛,超过80%的CP患者受到腹痛的影响。CP引起的腹部疼痛通常会使人衰弱,并降低生活质量(QOL)。

      慢性胰腺炎(CP)是一种使人痛不欲生的胰腺疾病,它主要的症状是腹痛,超过80%的CP患者受到腹痛的影响。CP引起的腹部疼痛通常会使人衰弱,并降低生活质量(QOL),先前的研究已经评估了QOL及其在CP中的决定因素,但使患者焦虑不安的抑郁症很大程度上未得到探究。有证据表明,疼痛和抑郁症具有双向影响:增加一个人的抑郁严重程度将导致对疼痛更为敏感。因此,本项研究旨在研究CP患者的焦虑和抑郁的患病率及其相关的患者和疾病特征以及对QOL的影响。

 

      这是一项横断面的多中心的前瞻性研究,研究人员使用焦虑和抑郁量表对患者进行筛查。在各自的焦虑或抑郁量表上,医院焦虑和抑郁量表得分> 7表示存在焦虑或抑郁,并被用作精神疾病合并症的诊断指标。最后研究人员比较了有和没有精神病合并症的患者的人口统计学,疾病特征,生活质量(EORTC-QLQ-C30)和疼痛症状的差异。

 

      本项研究共纳入111名CP患者(平均年龄53.8±13.7岁,男性占60%)。80(46.8%)和66(38.6%)名患者分别存在焦虑和抑郁,其中50人(29%)的焦虑和抑郁是重叠的。焦虑或抑郁症患者的疼痛发生率,疼痛严重程度和疼痛干扰评分较高(P <0.001)。精神病合并症也与全球健康评分和功能分量表降低有关(P <0.001),这些患者的临床症状负荷也更重(P ≤0.03)。最后,研究人员发现患者健康状况与抑郁之间存在独立的关联(P <0.001)。

 

      精神疾病在CP患者中普遍存在,并会加重疼痛和降低QOL评分。焦虑对QOL的影响可能通过疼痛来介导,而抑郁与QOL独立相关。

 

原始出处:

Phillips, Anna Evans. Et al. Psychiatric Comorbidity in Patients With Chronic Pancreatitis Associates With Pain and Reduced Quality of Life. The American Journal of Gastroenterology.2020.

 

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    2021-02-28 minzju5052
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    2020-12-27 oo902

    合并有精神症状的慢性胰腺炎患者其疼痛及生活质量均会明显恶化

    0

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    2020-12-27 oo902

    疼痛及生活质量均会明显恶化

    0

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    2020-12-27 GLL

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2032046, encodeId=8023203204681, content=<a href='/topic/show?id=07c4e6558d5' target=_blank style='color:#2F92EE;'>#精神症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76558, encryptionId=07c4e6558d5, topicName=精神症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri Nov 05 15:34:19 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057316, encodeId=dd96205e3161f, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Sun Feb 28 01:34:19 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911303, encodeId=8dea9113033a, content=合并有精神症状的慢性胰腺炎患者其疼痛及生活质量均会明显恶化, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:15:24 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911331, encodeId=16e191133100, content=疼痛及生活质量均会明显恶化, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:35:56 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911433, encodeId=bea0911433e8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b065448113, createdName=GLL, createdTime=Sun Dec 27 22:27:25 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911289, encodeId=931d9112893f, content=好好学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Dec 27 18:20:37 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911274, encodeId=3fd69112e4c0, content=已学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201225/6e1ef4f864494d0284b9282bc4cafc19/f7f10a42767b46c9823f11c34f905873.jpg, createdBy=145f5447474, createdName=ms6000001700483633, createdTime=Sun Dec 27 17:44:04 CST 2020, time=2020-12-27, status=1, ipAttribution=)]
    2020-12-27 jyzxjiangqin

    好好学习!

    0

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    2020-12-27 ms6000001700483633

    已学习

    0

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