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PLos One:骨关节炎疼痛的预后因素

2020-01-12 xiangting MedSci原创

这项研究结果表明,尽管OA患者在TJR后测试的临床和生物社会心理指标改变,但其术前值并不能预测术后疼痛。

相当一部分骨关节炎患者(OA)在全关节置换术(TJR)后继续承受中至重度疼痛。主要使用个体预测指标和明显的疼痛结局来研究与疼痛持续相关的术前因素,从而导致对术前指标对TJR术后疼痛的影响缺乏共识

这项前瞻性观察研究评估了TJR术前、术后3个月和6个月的膝和髋关节OA患者,寻找疼痛持续性的临床预测指标。研究评估了质量、情绪、情感、健康和生活质量的多种指标,以及放射学评估和基于表现的任务,对四种不同的疼痛结局进行了建模。将多元回归模型和网络分析应用于疼痛相关生物心理社会指标及其随手术的变化。

共有106名患者完成了研究。术前疼痛水平与术后残余疼痛无关。尽管不同的疼痛量表与术后疼痛的不同方面相关,但多因素模型不能可靠地预测膝部OA的术后疼痛(跨越四个不同的疼痛量表),并且不能推广到髋部OA。然而,网络分析显示,两组患者生物心理社会定义的OA人格在术后均发生了显著变化。

这项研究结果表明,尽管OA患者在TJR后测试的临床和生物社会心理指标改变,但其术前值并不能预测术后疼痛。获取TJR后疼痛持续性的预后指标需要对潜在机制有更全面的了解。

原始出处:

Joana Barroso. Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement? PLos One. January 2020.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 

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    2020-03-20 lisa438
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    2020-01-14 lmm397
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