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Diabetes Care:DPTRS有助鉴别1型糖尿病临床前状态

2012-05-06 沐雨译 医学论坛网

  有研究者评价了糖尿病预防试验—1型危险评分(DPTRS)对于2年内有可能进展为1型糖尿病的个体的鉴别能力。结果发现,DPTRS阈值为9.00可鉴别在2年内极可能被常规诊断为1型糖尿病的患者,这对于糖尿病临床前期非常重要。该研究4月30日在线发表于《糖尿病护理》(Diabetes Care)杂志。   DPTRS的组分包括C肽和口服葡萄糖耐力试验的葡萄糖指数,以及年龄和体质指数,该评

  有研究者评价了糖尿病预防试验—1型危险评分(DPTRS)对于2年内有可能进展为1型糖尿病的个体的鉴别能力。结果发现,DPTRS阈值为9.00可鉴别在2年内极可能被常规诊断为1型糖尿病的患者,这对于糖尿病临床前期非常重要。该研究4月30日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  DPTRS的组分包括C肽和口服葡萄糖耐力试验的葡萄糖指数,以及年龄和体质指数,该评分来自糖尿病预防试验—1型(DPT-1),并在TrialNet自然史研究(TNNHS)得到验证。

  评价结果表明,在DPT-1和TNNHS中,DPTRS阈值超过9.00后的2年危险分别为0.88和0.77。在DPT-1中,首次发生血糖代谢障碍和2小时血糖首次达到为190~199 mg/dl后的2年进展危险更低。在DPT-1中发生1型糖尿病的患者中,超过9.00阈值先于常规诊断0.81 (± 0.53)年。当首次超出9.00的阈值时,负荷后C肽水平较诊断时的水平显著升高。

  链接:

  The Application of the Diabetes Prevention Trial–Type 1 Risk Score for Identifying a Preclinical State of Type 1 Diabetes

  



    

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    2012-10-31 kord1982
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    2012-06-13 zhaojie88

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