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Nature Cell Biology:日美科学家发现造血干细胞持续造血机理

2017-03-20 佚名 科技部

日本九州大学研究生院与美国Albert Einstein医科大学的联合研究小组在世界上首次发现,间叶干细胞也可以根据遗传基因及蛋白质表达进行分类,而且它们还能形成各种细胞活素(维持干细胞造血功能的物质)。这一发现为弄清生命体内维持干细胞功能的复杂机制,打开了一个缺口, 有可能对研究形成高效增殖造血干细胞新方法,乃至加快再生医疗发展作出贡献。

初期的生命由一个干细胞发育而成。根据近年的研究,干细胞不仅存在于胎儿期,在成年人的各个脏器中,都存在着能够使该脏器再生的“脏器特异干细胞”。这些细胞具备终身无限增殖的能力,但通常情况下由于受到严格限制而多数处于“休眠状态”;在脏器受到损害等情况时,则根据需要发生增殖、分化。干细胞仅在特殊环境下“休眠”,这种环境被称作“龛”。



在我们的血液中有制造红血球、白血球、血小板等各类血细胞的“造血干细胞”,造血干细胞主要存在于骨髄中。此前人们已经知道,作为形成骨头等源头的间叶干细胞正是那种“细胞龛”,但其具体机理则不清楚。

日本九州大学研究生院与美国Albert Einstein医科大学的联合研究小组在世界上首次发现,间叶干细胞也可以根据遗传基因及蛋白质表达进行分类,而且它们还能形成各种细胞活素(维持干细胞造血功能的物质)。这一发现为弄清生命体内维持干细胞功能的复杂机制,打开了一个缺口, 有可能对研究形成高效增殖造血干细胞新方法,乃至加快再生医疗发展作出贡献。

该成果发表在2017年2月20日的《Nature Cell Biology》电子版上。

原始出处:
Noboru Asada,Yuya Kunisaki,Halley Pierce,et al. Differential cytokine contributions of perivascular haematopoietic stem cell niches.Nature Cell Biology . 20 February 2017.

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    2018-01-22 sunylz
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    2017-06-04 维他命
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GetPortalCommentsPageByObjectIdResponse(id=181446, encodeId=781018144620, content=造血干细胞终生可以造血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Mon Mar 20 15:39:41 CST 2017, time=2017-03-20, status=1, ipAttribution=)]
  5. 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    2017-12-29 liye789132251
  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=181446, encodeId=781018144620, content=造血干细胞终生可以造血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Mon Mar 20 15:39:41 CST 2017, time=2017-03-20, status=1, ipAttribution=)]
    2017-03-24 虈亣靌

    学习新知识谢谢分享

    0

  8. 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  9. 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GetPortalCommentsPageByObjectIdResponse(id=181446, encodeId=781018144620, content=造血干细胞终生可以造血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Mon Mar 20 15:39:41 CST 2017, time=2017-03-20, status=1, ipAttribution=)]
    2017-03-22 俅侠
  10. 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    2017-03-20 邓启付

    造血干细胞终生可以造血。

    0

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