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Blood:多发性骨髓瘤的治疗进展

2018-07-03 MedSci MedSci原创

随着免疫调节剂、蛋白酶体抑制剂和单克隆抗体等新型药物的引进,多发性骨髓瘤的治疗发生重大变化。现已证实,这些药物与常规化疗药物相比疗效更显著、耐受性更好,随着这些药物被引入临床应用,存活率大大提高。此外,更好地了解疾病生物学,可进一步提高诊断标准、促进开发特异而敏感的疾病预测工具,进而提高预后。现可根据宿主和疾病特征以及加强监测治疗反应和应用高敏感的评估残余病灶的技术个性化年轻患者的治疗。新药物显著

随着免疫调节剂、蛋白酶体抑制剂和单克隆抗体等新型药物的引进,多发性骨髓瘤的治疗发生重大变化。现已证实,这些药物与常规化疗药物相比疗效更显著、耐受性更好,随着这些药物被引入临床应用,存活率大大提高。

此外,更好地了解疾病生物学,可进一步提高诊断标准、促进开发特异而敏感的疾病预测工具,进而提高预后。现可根据宿主和疾病特征以及加强监测治疗反应和应用高敏感的评估残余病灶的技术个性化年轻患者的治疗。

新药物显著提高了当下的治疗标准,治疗模式向选择性或延迟进行自体干细胞移植(ASCT)作为部分患者的合理选择转变。

与此相反,延长治疗和诱导缓解,随后予以维持治疗,是目前的标准疗法;延长疾病控制时间,可更好的管理药物毒副作用,进而提高患者生活质量。

原始出处:

Sara Gandolfi, Claudia Paba Prada, and Paul Richardson. How I treat the young patient with multiple myeloma. Blood  2018  :blood-2017-05-693606;  doi: https://doi.org/10.1182/blood-2017-05-693606

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1889918, encodeId=846d1889918e7, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sat Mar 09 17:12:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329290, encodeId=b9e63292900c, content=延长治疗和诱导缓解.随后予以维持治疗.是目前的标准疗法,延长疾病控制时间.可更好的管理药物毒副作用.进而提高患者生活质量., beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:58:13 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329289, encodeId=a67f32928992, content=随着免疫调节剂.蛋白酶体抑制剂和单克隆抗体等新型药物的引进.多发性骨髓瘤的治疗发生重大变化, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:57:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329041, encodeId=0946329041c3, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Tue Jul 03 21:10:20 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2019-03-09 jml2009
  2. [GetPortalCommentsPageByObjectIdResponse(id=1889918, encodeId=846d1889918e7, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sat Mar 09 17:12:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329290, encodeId=b9e63292900c, content=延长治疗和诱导缓解.随后予以维持治疗.是目前的标准疗法,延长疾病控制时间.可更好的管理药物毒副作用.进而提高患者生活质量., beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:58:13 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329289, encodeId=a67f32928992, content=随着免疫调节剂.蛋白酶体抑制剂和单克隆抗体等新型药物的引进.多发性骨髓瘤的治疗发生重大变化, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:57:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329041, encodeId=0946329041c3, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Tue Jul 03 21:10:20 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-04 随梦飞扬

    延长治疗和诱导缓解.随后予以维持治疗.是目前的标准疗法,延长疾病控制时间.可更好的管理药物毒副作用.进而提高患者生活质量.

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1889918, encodeId=846d1889918e7, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sat Mar 09 17:12:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329290, encodeId=b9e63292900c, content=延长治疗和诱导缓解.随后予以维持治疗.是目前的标准疗法,延长疾病控制时间.可更好的管理药物毒副作用.进而提高患者生活质量., beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:58:13 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329289, encodeId=a67f32928992, content=随着免疫调节剂.蛋白酶体抑制剂和单克隆抗体等新型药物的引进.多发性骨髓瘤的治疗发生重大变化, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:57:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329041, encodeId=0946329041c3, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Tue Jul 03 21:10:20 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-04 随梦飞扬

    随着免疫调节剂.蛋白酶体抑制剂和单克隆抗体等新型药物的引进.多发性骨髓瘤的治疗发生重大变化

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1889918, encodeId=846d1889918e7, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sat Mar 09 17:12:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329290, encodeId=b9e63292900c, content=延长治疗和诱导缓解.随后予以维持治疗.是目前的标准疗法,延长疾病控制时间.可更好的管理药物毒副作用.进而提高患者生活质量., beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:58:13 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329289, encodeId=a67f32928992, content=随着免疫调节剂.蛋白酶体抑制剂和单克隆抗体等新型药物的引进.多发性骨髓瘤的治疗发生重大变化, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Jul 04 19:57:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329041, encodeId=0946329041c3, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Tue Jul 03 21:10:20 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 戒馋,懒,贪

    谢谢分享学习了

    0

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