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新型长链非编码RNA(lncRNA)的生物信息学研究进展

2014-01-03 原佳沛,张浩文,鲁志 生物化学与生物物理学进展

非编码RNA长链非编码RNA非编码RNA预测机器学习
关注

   非编码RNA (noncoding RNA，ncRNA)是指不被翻译成蛋白质的一类RNA，近几年来关于它们的功能研究越来越引起人们的重视．现在已经发现了一些中小型ncRNA，比如 microRNA、snoRNA、tRNA等，但是关于长ncRNA(lncRNA)的研究还不够完善．本篇综述回顾了 ncRNA特别是 lncRNA的生物信息学研究进展，包括它们的研究历程

   非编码RNA (noncoding RNA，ncRNA)是指不被翻译成蛋白质的一类RNA，近几年来关于它们的功能研究越来越引起人们的重视．现在已经发现了一些中小型ncRNA，比如 microRNA、snoRNA、tRNA等，但是关于长ncRNA(lncRNA)的研究还不够完善．本篇综述回顾了 ncRNA特别是 lncRNA的生物信息学研究进展，包括它们的研究历程、基本特点、与疾病的关系，以及对已有的预测非编码RNA的计算机方法进行了分析和比较，并且介绍 了利用机器学习模型整合新一代高通量测序数据的方法．
新型长链非编码RNA(lncRNA)的生物信息学研究进展.pdf

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    2014-06-23 liuyong2980

    #生物信#

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    2014-10-05 yanjie6253_56072842

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    2014-02-14 d830384

    #非编码#

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    2014-02-02 张伟

    生物信息

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    2014-01-05 xzw113

    #lncRNA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1798438, encodeId=f0c61e984386e, content=<a href='/topic/show?id=ad896919381' target=_blank style='color:#2F92EE;'>#生物信#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69193, encryptionId=ad896919381, topicName=生物信)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 23 10:50:00 CST 2014, time=2014-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005613, encodeId=b31f2005613dc, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Sun Oct 05 03:50:00 CST 2014, time=2014-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743414, encodeId=a30b1e434144e, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Fri Feb 14 08:50:00 CST 2014, time=2014-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7196, encodeId=9f04e1968b, content=生物信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=张伟, createdTime=Sun Feb 02 16:29:00 CST 2014, time=2014-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301845, encodeId=4408130184525, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380404, encodeId=17d3138040497, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485803, encodeId=a6d11485803dc, content=<a href='/topic/show?id=d0f29e089a9' target=_blank style='color:#2F92EE;'>#长链非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97089, encryptionId=d0f29e089a9, topicName=长链非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5df38055979, createdName=minhuang75_72521586, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584618, encodeId=9e681584618be, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 mashirong

    #研究进展#

    0

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    2014-01-05 minhuang75_72521586

    #长链非编码RNA#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1798438, encodeId=f0c61e984386e, content=<a href='/topic/show?id=ad896919381' target=_blank style='color:#2F92EE;'>#生物信#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69193, encryptionId=ad896919381, topicName=生物信)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Mon Jun 23 10:50:00 CST 2014, time=2014-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005613, encodeId=b31f2005613dc, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Sun Oct 05 03:50:00 CST 2014, time=2014-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743414, encodeId=a30b1e434144e, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Fri Feb 14 08:50:00 CST 2014, time=2014-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7196, encodeId=9f04e1968b, content=生物信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=张伟, createdTime=Sun Feb 02 16:29:00 CST 2014, time=2014-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301845, encodeId=4408130184525, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380404, encodeId=17d3138040497, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485803, encodeId=a6d11485803dc, content=<a href='/topic/show?id=d0f29e089a9' target=_blank style='color:#2F92EE;'>#长链非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97089, encryptionId=d0f29e089a9, topicName=长链非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5df38055979, createdName=minhuang75_72521586, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584618, encodeId=9e681584618be, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 12498f6em12暂无昵称

    #编码#

    0

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