ACG 2015：慢性便秘是一种胃肠道疾病的预警信号

2015-10-27 zhaoshuang 译 MedSci原创

美国胃肠病学会2015年会上提出的一项新研究提示，成人慢性便秘可能预示着包括缺血性结肠炎、结肠直肠癌、胃癌、肠窒室等一些严重中的胃肠道疾病。Lauren Gerson博士提出，有慢性便秘时，不论年纪大小，有无胃肠道出血、贫血、体重减轻等胃肠道疾病危险信号时，都需要去检查。一些器质性的胃肠道疾病，比如结肠直肠癌，会出现慢性便秘症状，但是慢性便秘却不是发展成为结直肠癌以及其他一些严重的器质性胃肠道疾病

美国胃肠病学会2015年会上提出的一项新研究提示，成人慢性便秘可能预示着包括缺血性结肠炎、结肠直肠癌、胃癌、肠窒室等一些严重中的胃肠道疾病。

Lauren Gerson博士提出，有慢性便秘时，不论年纪大小，有无胃肠道出血、贫血、体重减轻等胃肠道疾病危险信号时，都需要去检查。一些器质性的胃肠道疾病，比如结肠直肠癌，会出现慢性便秘症状，但是慢性便秘却不是发展成为结直肠癌以及其他一些严重的器质性胃肠道疾病的风险因素。在美国，大约有15%的人有慢性便秘表现。

她的研究小组从从Humedica电子医疗记录SmartFile数据库对12838名18-50岁，从2008年到2013年至少维持了24个月慢性便秘随访治疗的成年患者进行了研究。

研究发现在5/6的疾病类别中，慢性便秘患者胃肠道疾病的风险明显高于没有慢性便秘的患者。虽然炎性肠道疾病引起严重胃肠道疾病的风险更高，但差异不显著(风险比 1.59)

慢性便秘患者的胃肠道疾病风险表

胃肠道疾病风险比

缺血性结肠炎 7.68

结肠直肠癌 6.26

胃癌 5.04

肠憩室炎 5.06

复合型胃肠道疾病 3.28

这些关系之前已经有实验证实过，但是没有详细探讨慢性便秘与这些疾病之间的风险比。

Lauren Gerson提出，肠窒室的窒息炎与慢性便秘之间有联系并不让人觉得诧异，因为这类病人往往会逐渐变胖并且活动力下降。但是慢性便秘与胃肠道癌症以及缺血性结肠炎之间的关系如此密切，确实令人惊讶。她们还将继续提取更多的信息观察便秘的持续时间与特定的胃肠道疾病之间的关系，这也是她们研究的最终目标。

原始出处：

Neil Osterweil.Chronic Constipation a Warning Sign for GI Disorders.Medscape Medical News.October 26, 2015

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2016-03-20 爆笑小医

#胃肠道疾病#

104 0
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2016-09-03 1249842em18(暂无昵称)

#ACG#

70 0
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2015-12-30 xyfg98

赞

177 0
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2015-11-05 maivera

赞

158 0
[GetPortalCommentsPageByObjectIdResponse(id=1666225, encodeId=f737166622513, content=<a href='/topic/show?id=9a42833423a' target=_blank style='color:#2F92EE;'>#胃肠道疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83342, encryptionId=9a42833423a, topicName=胃肠道疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Mar 20 22:48:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685516, encodeId=100f168551613, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Sat Sep 03 02:48:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50398, encodeId=c41950398dd, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:46:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42568, encodeId=87b842568dc, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160713/IMG578519F1E84C63307.jpg, createdBy=331b1635963, createdName=maivera, createdTime=Thu Nov 05 00:11:00 CST 2015, time=2015-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42554, encodeId=cd27425546b, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42555, encodeId=34514255504, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42556, encodeId=a8754255624, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42557, encodeId=19054255e44, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42558, encodeId=3ce442558be, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42213, encodeId=3a8a422136b, content=我也会出现, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Mon Nov 02 12:44:00 CST 2015, time=2015-11-02, status=1, ipAttribution=)]
2015-11-04 Wei Junhui

赞

146 0
[GetPortalCommentsPageByObjectIdResponse(id=1666225, encodeId=f737166622513, content=<a href='/topic/show?id=9a42833423a' target=_blank style='color:#2F92EE;'>#胃肠道疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83342, encryptionId=9a42833423a, topicName=胃肠道疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Mar 20 22:48:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685516, encodeId=100f168551613, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Sat Sep 03 02:48:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50398, encodeId=c41950398dd, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:46:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42568, encodeId=87b842568dc, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160713/IMG578519F1E84C63307.jpg, createdBy=331b1635963, createdName=maivera, createdTime=Thu Nov 05 00:11:00 CST 2015, time=2015-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42554, encodeId=cd27425546b, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42555, encodeId=34514255504, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42556, encodeId=a8754255624, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42557, encodeId=19054255e44, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42558, encodeId=3ce442558be, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42213, encodeId=3a8a422136b, content=我也会出现, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Mon Nov 02 12:44:00 CST 2015, time=2015-11-02, status=1, ipAttribution=)]
2015-11-04 Wei Junhui

赞

58 0
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2015-11-04 Wei Junhui

赞

179 0
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2015-11-04 Wei Junhui

赞

111 0
[GetPortalCommentsPageByObjectIdResponse(id=1666225, encodeId=f737166622513, content=<a href='/topic/show?id=9a42833423a' target=_blank style='color:#2F92EE;'>#胃肠道疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83342, encryptionId=9a42833423a, topicName=胃肠道疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Mar 20 22:48:00 CST 2016, time=2016-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685516, encodeId=100f168551613, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Sat Sep 03 02:48:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50398, encodeId=c41950398dd, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 12:46:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42568, encodeId=87b842568dc, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160713/IMG578519F1E84C63307.jpg, createdBy=331b1635963, createdName=maivera, createdTime=Thu Nov 05 00:11:00 CST 2015, time=2015-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42554, encodeId=cd27425546b, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42555, encodeId=34514255504, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42556, encodeId=a8754255624, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42557, encodeId=19054255e44, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42558, encodeId=3ce442558be, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151016/IMG56205A89715F55916.jpg, createdBy=23dd1656569, createdName=Wei Junhui, createdTime=Wed Nov 04 21:48:00 CST 2015, time=2015-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42213, encodeId=3a8a422136b, content=我也会出现, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Mon Nov 02 12:44:00 CST 2015, time=2015-11-02, status=1, ipAttribution=)]
2015-11-04 Wei Junhui

赞

175 0
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2015-11-02 nizongzan

我也会出现

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