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Thorax:普通人群中肥胖个体慢性咳嗽的风险和影响

2021-10-04 MedSci原创 MedSci原创

BMI与慢性咳嗽之间存在剂量-反应关系,肥胖个体的慢性咳嗽风险比一般人群高出2-3倍。这种增加的风险部分是由GERD、低蔬菜摄入量和职业接触所介导。

肥胖者患慢性咳嗽的风险更高。

近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员旨在调查普通人群中肥胖个体慢性咳嗽的风险和影响。

研究人员记录了来自哥本哈根一般人群研究的44554名成年人的慢性咳嗽、体重指数(BMI)和其他相关临床状况。排除患有哮喘和/或慢性阻塞性肺病的个体(n=10977)。BMI分为:体重过轻(BMI<18.5kg/m2)、正常体重(18.5-24.9kg/m2)、超重(25.0-29.9kg/m2)、肥胖(30.0-34.9kg/m2)和严重肥胖(≥35.0kg/m2)。

在来自一般人群的33577名成年人中,27829人(83%)为非肥胖者,5748人(17%)为肥胖者。与体重正常的个体相比,慢性咳嗽风险的多变量调整OR为:超重为1.4(95%CI为1.2至1.6),肥胖为1.9(95%CI为1.7至2.2),严重肥胖为2.6(95%CI为2.1至3.2)。介导分析表明,高达23%的肥胖引起的慢性咳嗽是由胃食管反流病(GERD)所致。其他介导因素包括10%的低蔬菜摄入量和8%的职业接触。在肥胖个体中,慢性咳嗽患者与没有慢性咳嗽的个体相比,伴随的呼吸道症状更严重,包括胃食管反流病和糖尿病在内的合并症更常见,医疗保健利用率更高,肺功能更低,血液中炎症水平更高(所有p<0.05)。

由此可见,BMI与慢性咳嗽之间存在剂量-反应关系,肥胖个体的慢性咳嗽风险比一般人群高出2-3倍。这种增加的风险部分是由GERD、低蔬菜摄入量和职业接触所介导。

原始出处:

Eskild Morten Landt,et al.Risk and impact of chronic cough in obese individuals from the general population.Thorax.2021.https://thorax.bmj.com/content/early/2021/09/29/thoraxjnl-2020-216351

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1614790, encodeId=7b0c1614e9086, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Wed Oct 06 03:56:39 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057742, encodeId=30d2105e74266, content=反正肥胖的坏处太多了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Tue Oct 05 07:11:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057629, encodeId=d1a4105e62903, content=倪敏卡路meal for6组词典k?, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Mon Oct 04 16:29:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057510, encodeId=7758105e510ff, content=谢谢!一胖毁所有,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=460b5587387, createdName=ms6000000133404500, createdTime=Mon Oct 04 14:04:34 CST 2021, time=2021-10-04, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1614790, encodeId=7b0c1614e9086, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Wed Oct 06 03:56:39 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057742, encodeId=30d2105e74266, content=反正肥胖的坏处太多了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Tue Oct 05 07:11:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057629, encodeId=d1a4105e62903, content=倪敏卡路meal for6组词典k?, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Mon Oct 04 16:29:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057510, encodeId=7758105e510ff, content=谢谢!一胖毁所有,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=460b5587387, createdName=ms6000000133404500, createdTime=Mon Oct 04 14:04:34 CST 2021, time=2021-10-04, status=1, ipAttribution=)]
    2021-10-05 小小的丁香花

    反正肥胖的坏处太多了。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1614790, encodeId=7b0c1614e9086, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Wed Oct 06 03:56:39 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057742, encodeId=30d2105e74266, content=反正肥胖的坏处太多了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Tue Oct 05 07:11:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057629, encodeId=d1a4105e62903, content=倪敏卡路meal for6组词典k?, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Mon Oct 04 16:29:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057510, encodeId=7758105e510ff, content=谢谢!一胖毁所有,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=460b5587387, createdName=ms6000000133404500, createdTime=Mon Oct 04 14:04:34 CST 2021, time=2021-10-04, status=1, ipAttribution=)]
    2021-10-04 查查佳佳

    倪敏卡路meal for6组词典k?

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1614790, encodeId=7b0c1614e9086, content=<a href='/topic/show?id=b77f59959f2' target=_blank style='color:#2F92EE;'>#普通人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59959, encryptionId=b77f59959f2, topicName=普通人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b9519540847, createdName=ms9476844295372110, createdTime=Wed Oct 06 03:56:39 CST 2021, time=2021-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057742, encodeId=30d2105e74266, content=反正肥胖的坏处太多了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Tue Oct 05 07:11:10 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057629, encodeId=d1a4105e62903, content=倪敏卡路meal for6组词典k?, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Mon Oct 04 16:29:12 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057510, encodeId=7758105e510ff, content=谢谢!一胖毁所有,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=460b5587387, createdName=ms6000000133404500, createdTime=Mon Oct 04 14:04:34 CST 2021, time=2021-10-04, status=1, ipAttribution=)]
    2021-10-04 ms6000000133404500

    谢谢!一胖毁所有,学习了

    0

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