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J Urol:局部高等级前列腺癌的初步治疗中,手术治疗和放射治疗癌症特异性死亡率评估

2019-01-02 AlexYang MedSci原创

年龄稍小男性中局部高等级前列腺癌的最优初始治疗手段仍旧是有争议的。最近,有研究人员比较了起始根治性前列腺切除和放射治疗对小于60岁男性生存结果的影响。研究包括了2228名男性,其中1459名(65.5%)经历了起始手术治疗,平均跟踪调查的时间为43个月,769名(34.5%)男性经历了体外放射治疗,带有或者不带有近距离放射治疗,平均跟踪调查的时间为44个月。在多变量分析中,在控制了年龄、生物活检格

年龄稍小男性中局部高等级前列腺癌的最优初始治疗手段仍旧是有争议的。最近,有研究人员比较了起始根治性前列腺切除和放射治疗对小于60岁男性生存结果的影响。

研究包括了2228名男性,其中1459名(65.5%)经历了起始手术治疗,平均跟踪调查的时间为43个月,769名(34.5%)男性经历了体外放射治疗,带有或者不带有近距离放射治疗,平均跟踪调查的时间为44个月。在多变量分析中,在控制了年龄、生物活检格林森评分和前列腺特异性抗原等变量后,与起始治疗使用放射治疗相比,起始治疗使用手术治疗的与前列腺癌特异性和总生存率的改善相关(HR 0.37, 95% CI 0.19-0.74, p=0.005 vs HR 0.41, 95% CI 0.24-0.70, p=0.001)。

最后,研究人员指出,他们的数据表明了年轻男性高等级前列腺癌患者中,使用手术治疗要比放射治疗具有显著更好的生存率。研究人员也指出,进一步的前瞻性随机试验是需要的,从而进一步确认这些治疗方法的长期结果情况。

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    2019-01-04 chg122

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