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Circulation：急性心梗患者他汀强化和剂量很大化率较低

2014-02-11 高晓方 译 医学论坛网

急性心梗患者他汀强化调脂
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美国一项研究表明，绝大部分急性心梗患者在住院期间启用了他汀类治疗，但他汀类强化和剂量最大化治疗率较低，并且具有显著的院间差异。论文2月4日在线发表于《循环》(Circulation)。【原文下载】 此项研究从24所医院中纳入了4340例急性心梗患者。对包括LDL-C在内的患者因素进行校正之后，利用层次模型分别在初治患者中评估他汀类启用院间变异，在次最大治疗剂量患者中评估强化治疗院间变异，

美国一项研究表明，绝大部分急性心梗患者在住院期间启用了他汀类治疗，但他汀类强化和剂量最大化治疗率较低，并且具有显著的院间差异。论文2月4日在线发表于《循环》(Circulation)。【原文下载】

此项研究从24所医院中纳入了4340例急性心梗患者。对包括LDL-C在内的患者因素进行校正之后，利用层次模型分别在初治患者中评估他汀类启用院间变异，在次最大治疗剂量患者中评估强化治疗院间变异，以及出院时最大剂量治疗院间变异。利用中位比率(MRR)评估院间变异。

结果显示，在他汀类初治患者中，87%的无禁忌证患者接受了他汀类治疗，并且无院间变异(MRR 1.02)。在次最大剂量他汀类治疗的患者中，26%接受了强化他汀类治疗，并具有轻度院间变异(MRR 1.47)。在所有无禁忌症的患者中，26%在出院时接受了最大剂量他汀类治疗，并具有显著院间变异(MRR 2.79)。

原始出处：

Arnold SV, Kosiborod M, Tang F, Zhao Z, Maddox TM, McCollam PL, Birt J, Spertus JA.Patterns of Statin Initiation, Intensification, and Maximization Among Patients Hospitalized with an Acute Myocardial Infarction.Circulation. 2014 Feb 4. 【原文下载】

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    2014-06-29 lidage

    吸取教训，强化他汀治疗

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=10186, encodeId=5f49101861b, content=吸取教训，强化他汀治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 18:08:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049443, encodeId=43372049443ef, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Jun 24 00:38:00 CST 2014, time=2014-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7396, encodeId=9fcee3962c, content=挺好的，学习借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Fri Feb 14 11:03:00 CST 2014, time=2014-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308313, encodeId=b6051308313a8, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=)]
    2014-06-24 zhanglin3079

    #心梗患者#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=10186, encodeId=5f49101861b, content=吸取教训，强化他汀治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 18:08:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049443, encodeId=43372049443ef, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Jun 24 00:38:00 CST 2014, time=2014-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7396, encodeId=9fcee3962c, content=挺好的，学习借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Fri Feb 14 11:03:00 CST 2014, time=2014-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308313, encodeId=b6051308313a8, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=)]
    2014-02-14 gongzuozhong

    挺好的，学习借鉴

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=10186, encodeId=5f49101861b, content=吸取教训，强化他汀治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a03104789, createdName=lidage, createdTime=Sun Jun 29 18:08:00 CST 2014, time=2014-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049443, encodeId=43372049443ef, content=<a href='/topic/show?id=5c2e5106290' target=_blank style='color:#2F92EE;'>#心梗患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51062, encryptionId=5c2e5106290, topicName=心梗患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Tue Jun 24 00:38:00 CST 2014, time=2014-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7396, encodeId=9fcee3962c, content=挺好的，学习借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150602/IMG556D2C119C3EC8067.jpg, createdBy=e2ea89702, createdName=gongzuozhong, createdTime=Fri Feb 14 11:03:00 CST 2014, time=2014-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308313, encodeId=b6051308313a8, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=)]
    2014-02-13 chenlianhui

    #急性心梗#

    0

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