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PNAS：抗癌药阿瓦斯丁和舒尼替尼增加乳腺癌干细胞数量

2012-02-06 MedSci MedSci原创

阿瓦斯丁舒尼替尼乳腺癌干细胞
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 MedSci评论：     本研究主要显示靶向制剂因为抗血管新生，从而导致肿瘤细胞缺氧，而这种状态能够促进“乳腺癌干细胞”。但是这仅是初步研究，还有很长的路要走：（1）缺氧是如何导致乳腺癌干细胞数量增加？机制是什么？（2）如果阿瓦斯丁和舒尼替尼是这样，那么抗血管新生这条路下一步该如何走？     当然，研究毕竟是研

 MedSci评论：     本研究主要显示靶向制剂因为抗血管新生，从而导致肿瘤细胞缺氧，而这种状态能够促进“乳腺癌干细胞”。但是这仅是初步研究，还有很长的路要走：（1）缺氧是如何导致乳腺癌干细胞数量增加？机制是什么？（2）如果阿瓦斯丁和舒尼替尼是这样，那么抗血管新生这条路下一步该如何走？     当然，研究毕竟是研究，不是临床，还没这么可怕。因为许多靶向药物与传统化疗药配合使用，而传统化疗药多是破坏性的治疗，杀伤肿瘤同时，有可能对实体瘤的缺氧状态有所改善（即使不阻断新生血管，实体瘤内部也是缺氧状态）。因此，有效给合不同治疗的优势，是能够找到最佳的组合方案的。     另外，治疗肿瘤还有很多新的思路，也有一些新的药物在研发之中，如近年来不少研究认为抑制肿瘤细胞线粒体的呼吸功能，可能是重要一条途径，它虽然与阻断血管诱导缺氧不同，那么，这种饥饿肿瘤的方法也会有类似的作用吗？不管最终结果如何，需要反思肿瘤的治疗。 乳腺癌转移的整合模型，图片来自Nature Reviews Cancer 5,

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1855236, encodeId=e80018552366a, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri Mar 09 14:37:00 CST 2012, time=2012-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935563, encodeId=776a1935563e4, content=<a href='/topic/show?id=46a723e4521' target=_blank style='color:#2F92EE;'>#乳腺癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23745, encryptionId=46a723e4521, topicName=乳腺癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun Feb 19 11:37:00 CST 2012, time=2012-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314555, encodeId=cd9b13145551c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544941, encodeId=de6d154494161, content=<a href='/topic/show?id=7a0fe1289c2' target=_blank style='color:#2F92EE;'>#癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71289, encryptionId=7a0fe1289c2, topicName=癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340013676140, createdName=1249898am19暂无昵称, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=)]
    2012-03-09 drwjr

    #PNAS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1855236, encodeId=e80018552366a, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri Mar 09 14:37:00 CST 2012, time=2012-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935563, encodeId=776a1935563e4, content=<a href='/topic/show?id=46a723e4521' target=_blank style='color:#2F92EE;'>#乳腺癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23745, encryptionId=46a723e4521, topicName=乳腺癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun Feb 19 11:37:00 CST 2012, time=2012-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314555, encodeId=cd9b13145551c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544941, encodeId=de6d154494161, content=<a href='/topic/show?id=7a0fe1289c2' target=_blank style='color:#2F92EE;'>#癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71289, encryptionId=7a0fe1289c2, topicName=癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340013676140, createdName=1249898am19暂无昵称, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=)]
    2012-02-19 ms7899726347904398

    #乳腺癌干细胞#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1855236, encodeId=e80018552366a, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri Mar 09 14:37:00 CST 2012, time=2012-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935563, encodeId=776a1935563e4, content=<a href='/topic/show?id=46a723e4521' target=_blank style='color:#2F92EE;'>#乳腺癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23745, encryptionId=46a723e4521, topicName=乳腺癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun Feb 19 11:37:00 CST 2012, time=2012-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314555, encodeId=cd9b13145551c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544941, encodeId=de6d154494161, content=<a href='/topic/show?id=7a0fe1289c2' target=_blank style='color:#2F92EE;'>#癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71289, encryptionId=7a0fe1289c2, topicName=癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340013676140, createdName=1249898am19暂无昵称, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=)]
    2012-02-08 sunylz

    #抗癌药#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1855236, encodeId=e80018552366a, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Fri Mar 09 14:37:00 CST 2012, time=2012-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935563, encodeId=776a1935563e4, content=<a href='/topic/show?id=46a723e4521' target=_blank style='color:#2F92EE;'>#乳腺癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23745, encryptionId=46a723e4521, topicName=乳腺癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun Feb 19 11:37:00 CST 2012, time=2012-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314555, encodeId=cd9b13145551c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544941, encodeId=de6d154494161, content=<a href='/topic/show?id=7a0fe1289c2' target=_blank style='color:#2F92EE;'>#癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71289, encryptionId=7a0fe1289c2, topicName=癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340013676140, createdName=1249898am19暂无昵称, createdTime=Wed Feb 08 13:37:00 CST 2012, time=2012-02-08, status=1, ipAttribution=)]
    2012-02-08 1249898am19暂无昵称

    #癌干细胞#

    0

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