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Circulation:感染SARS-CoV-2的年轻运动员心脏受累情况

2021-04-18 MedSci原创 MedSci原创

SARS-CoV-2感染的年轻运动员短期随访中心脏受累患病率和临床事件风险均较低。

重症急性呼吸综合征冠状病毒2(SARS-CoV-2)住院患者心脏受累较为常见,并与不良结局相关。近日,血管领域权威杂志Circulation上发表了一篇研究文章,这项研究旨在明确年轻运动员感染SARS-CoV-2后心脏受累的患病率及其临床意义。

在这项前瞻性多中心观察性队列研究中,研究人员从42所大学的数据中评估了美国大学生运动员中因SARS-CoV-2感染心脏受累的患病率、临床特征以及结局。数据收集自2020年9月1日至2020年12月31日。该研究的主要结局是根据更新的路易斯湖准则所定义的影像学明确的、极可能的或可能发生的SARS-CoV-2心脏受累的患病率。次要结局包括心脏检测的诊断率,心脏受累的预测因子以及不良心血管事件或住院。

在19378名接受SARS-CoV-2感染检测的运动员中,3018名(平均年龄为20岁[SD,1岁];32%为女性)运动员检测呈阳性并接受了心脏评估。共有2820名运动员接受了至少一项心脏“三联”检查[12导联心电图(ECG)、肌钙蛋白和/或经胸超声心动图(TTE)],然后在临床上进行了心脏磁共振(CMR)检查。

相比之下,研究人员对198名运动员进行了CMR初筛。ECG(21/2999,0.7%)、心肌肌钙蛋白(24/2719,0.9%)和TTE(24/2556,0.9%)检测发现伴有SARS-CoV-2心脏受累。在21/3018(0.7%)名运动员中确诊了明确的、极可能的或可能发生的SARS-CoV-2心脏受累,其中,15/2820(0.5%)名患者接受了临床指征的CMR检查(n=119),6/198(3.0%)名患者接受了CMR初筛。因此,与初筛CMR(6/198,3.0%)相比,临床指示的CMR(15/119,12.6%)对SARS-COV-2心脏受累的CMR诊断率提高了4.2倍。调整种族和性别后,SARS-CoV-2感染后心脏受累的预测因素包括心肺症状(OR:3.1,95%CI为1.2,7.7)或至少一项异常的三联检查结果(OR:37.4,95%CI为13.3,105.3)。5名(0.2%)运动员因SARS-CoV-2感染的非心脏并发症而需要住院治疗。在临床监测期间(中位随访为113天[IQR=90,146]),有1例(0.03%)患者不良心脏事件可能与SARS-CoV-2感染无关。

由此可见,SARS-CoV-2感染的年轻运动员短期随访中心脏受累患病率和临床事件风险均较低

原始出处:

Nathaniel Moulson,et al.SARS-CoV-2 Cardiac Involvement in Young Competitive Athletes.Circulation. 2021.https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.054824

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    2021-11-03 hukaixun
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    2021-04-20 小刀医生
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    2021-04-20 gujh
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    2021-04-18 jyzxjiangqin

    好文章!

    0

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