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新方法可有效治疗抗NMDA受体脑炎

2017-01-10 Andreas Meisel 《神经学》

 

德国研究人员最新发现,一种治疗血液肿瘤的药物可用于治疗抗NMDA受体脑炎,有效治疗重症患者。

抗NMDA受体脑炎即抗N—甲基—D—天冬氨酸受体脑炎,是一种自体免疫性疾病,因大脑炎症而引发精神分裂、癫痫、运动障碍等症状,严重时可导致患者死亡。近年来,这种多发于女性的脑炎受到医学界的重视。

德国柏林沙里泰大学医院和德国神经退行性疾病研究中心研究人员发现,现有标准疗法对脑炎重症患者疗效有限,而在标准疗法基础上加入药物硼替佐米后,受试的5名重症患者症状迅速改善。硼替佐米是一种蛋白酶体抑制剂,原用于治疗罕见的血液肿瘤——浆细胞瘤。

研究人员介绍,NMDA受体在大脑信号传输过程中起到重要作用,但在抗NMDA受体脑炎患者体内,浆细胞会产生抗体,妨碍NMDA受体正常运转。硼替佐米可有效杀死浆细胞,从而使抗体减少、根治此类脑炎,为重症患者带来新疗法选项。

这项研究成果发表在新一期国际学术期刊《神经学》上。(来源:新华社)

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1903182, encodeId=e8dd1903182e2, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Mon Mar 13 09:36:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241349, encodeId=42cb241349fc, content=这么说基本浆细胞增生或反应性的都能用此类药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fo79zus88qcdVNuibzPEwK5qSZeDdNfBibjicjTDoblgHZoUnfj6jXEb4RhbicHLMSJBrFO51KoTsjYibZyjqCFYW4A/132, createdBy=94671662726, createdName=tsong2010, createdTime=Thu Sep 07 07:45:53 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030212, encodeId=09482030212d2, content=<a href='/topic/show?id=4a67128814c' target=_blank style='color:#2F92EE;'>#NMDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12881, encryptionId=4a67128814c, topicName=NMDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Wed Mar 15 14:36:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943542, encodeId=893a194354299, content=<a href='/topic/show?id=daad11404a3' target=_blank style='color:#2F92EE;'>#MDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11404, encryptionId=daad11404a3, topicName=MDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Fri May 26 09:36:00 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343564, encodeId=3cf91343564f7, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Thu Jan 12 01:36:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619456, encodeId=471f1619456b0, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jan 12 01:36:00 CST 2017, time=2017-01-12, status=1, ipAttribution=)]
    2017-09-07 tsong2010

    这么说基本浆细胞增生或反应性的都能用此类药物

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1903182, encodeId=e8dd1903182e2, content=<a href='/topic/show?id=e1b0583884b' target=_blank style='color:#2F92EE;'>#新方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58388, encryptionId=e1b0583884b, topicName=新方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Mon Mar 13 09:36:00 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241349, encodeId=42cb241349fc, content=这么说基本浆细胞增生或反应性的都能用此类药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fo79zus88qcdVNuibzPEwK5qSZeDdNfBibjicjTDoblgHZoUnfj6jXEb4RhbicHLMSJBrFO51KoTsjYibZyjqCFYW4A/132, createdBy=94671662726, createdName=tsong2010, createdTime=Thu Sep 07 07:45:53 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030212, encodeId=09482030212d2, content=<a href='/topic/show?id=4a67128814c' target=_blank style='color:#2F92EE;'>#NMDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12881, encryptionId=4a67128814c, topicName=NMDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Wed Mar 15 14:36:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943542, encodeId=893a194354299, content=<a href='/topic/show?id=daad11404a3' target=_blank style='color:#2F92EE;'>#MDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11404, encryptionId=daad11404a3, topicName=MDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Fri May 26 09:36:00 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343564, encodeId=3cf91343564f7, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Thu Jan 12 01:36:00 CST 2017, time=2017-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619456, encodeId=471f1619456b0, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jan 12 01:36:00 CST 2017, time=2017-01-12, status=1, ipAttribution=)]
    2017-05-26 wetgdt
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