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Diabetes Care：自体造血干细胞移植为1型糖尿病带来希望

2012-07-06 陈智 中国医学论坛报

1型糖尿病患者治疗造血干细胞
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  　　7月的《糖尿病护理》[Diabetes Care 2012,35（7）：1413]杂志发表了上海交通大学附属瑞金医院宁光教授等的一项研究，结果显示，自体非清髓性造血干细胞移植（AHSCT）可作为胰岛素依赖患者的一种长期有效的治疗手段，特别是对诊断时未发现酮症酸中毒的患者，可能治疗更为有效。 　　该前瞻性AHSCT第2阶段临床研究中共纳入了28例1型糖尿病患者。结果显

带给1型糖尿病患者治疗“新希望”

 

　　7月的《糖尿病护理》[Diabetes Care 2012,35（7）：1413]杂志发表了上海交通大学附属瑞金医院宁光教授等的一项研究，结果显示，自体非清髓性造血干细胞移植（AHSCT）可作为胰岛素依赖患者的一种长期有效的治疗手段，特别是对诊断时未发现酮症酸中毒的患者，可能治疗更为有效。

　　该前瞻性AHSCT第2阶段临床研究中共纳入了28例1型糖尿病患者。结果显示，进行AHSCT后，15例患者（53.6%）在平均19.3个月时先后完全缓解（即不依赖于胰岛素）。非糖尿病酮症酸中毒的患者完全缓解率高于糖尿病酮症酸中毒患者（P=0.051）。

　　■ 研究者说

　　上海交通大学附属瑞金医院宁光教授：该临床试验设计并实施于2008年初，由上海瑞金医院和南京鼓楼医院共同完成，其结果引发了国外同行的广泛关注和兴趣。自体造血干细胞在从系统性红斑狼疮及类风湿关节炎等自身免疫性疾病衍生至1A型糖尿病的治疗后，充分显示了其免疫抑制和促胰岛再生的优势。虽然目前仍缺乏确切的基础研究数据支持，但临床试验结果显示了其提高C肽水平和停用胰岛素注射的疗效明显优于任何一种单一的免疫干预药物和抗炎药物。

　　自体造血干细胞移植让我们对初发1A型糖尿病的治疗充满信心。希望更多的国内同行投身于自主研发的临床试验研究中，在国际舞台上发出响亮的中国声音！   

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    2013-06-01 木头人513

    #Diabetes#

    0

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    2012-10-14 limedical1982

    #细胞移植#

    0

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    2012-10-20 ms9608593228839890

    #DIA#

    0

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    2013-03-29 ms5439512287675881

    #BET#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1900960, encodeId=69021900960b1, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 01 16:41:00 CST 2013, time=2013-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658742, encodeId=e7ec1658e4272, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Sun Oct 14 14:41:00 CST 2012, time=2012-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636518, encodeId=2505163651831, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Oct 20 23:41:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759151, encodeId=449f1e5915125, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Mar 29 10:41:00 CST 2013, time=2013-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4521, encodeId=a06c45212a, content=这一临床试验进行的怎么样, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=125.121.131.139, createdTime=Fri Jul 13 22:52:00 CST 2012, time=2012-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271344, encodeId=3bf012e13440c, content=<a href='/topic/show?id=a0ff950018f' target=_blank style='color:#2F92EE;'>#造血干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95001, encryptionId=a0ff950018f, topicName=造血干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e729101, createdName=huanbaofeng, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494466, encodeId=9ee21494466fd, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534992, encodeId=72331534992fb, content=<a href='/topic/show?id=f92a8602447' target=_blank style='color:#2F92EE;'>#自体造血干细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86024, encryptionId=f92a8602447, topicName=自体造血干细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02d712580056, createdName=dongjia2014, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=)]
    2012-07-13 125.121.131.139

    这一临床试验进行的怎么样

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1900960, encodeId=69021900960b1, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 01 16:41:00 CST 2013, time=2013-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658742, encodeId=e7ec1658e4272, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Sun Oct 14 14:41:00 CST 2012, time=2012-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636518, encodeId=2505163651831, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Oct 20 23:41:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759151, encodeId=449f1e5915125, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Mar 29 10:41:00 CST 2013, time=2013-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4521, encodeId=a06c45212a, content=这一临床试验进行的怎么样, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=125.121.131.139, createdTime=Fri Jul 13 22:52:00 CST 2012, time=2012-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271344, encodeId=3bf012e13440c, content=<a href='/topic/show?id=a0ff950018f' target=_blank style='color:#2F92EE;'>#造血干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95001, encryptionId=a0ff950018f, topicName=造血干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e729101, createdName=huanbaofeng, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494466, encodeId=9ee21494466fd, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534992, encodeId=72331534992fb, content=<a href='/topic/show?id=f92a8602447' target=_blank style='color:#2F92EE;'>#自体造血干细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86024, encryptionId=f92a8602447, topicName=自体造血干细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02d712580056, createdName=dongjia2014, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=)]
    2012-07-08 huanbaofeng

    #造血干细胞#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1900960, encodeId=69021900960b1, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 01 16:41:00 CST 2013, time=2013-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658742, encodeId=e7ec1658e4272, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Sun Oct 14 14:41:00 CST 2012, time=2012-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636518, encodeId=2505163651831, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Oct 20 23:41:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759151, encodeId=449f1e5915125, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Mar 29 10:41:00 CST 2013, time=2013-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4521, encodeId=a06c45212a, content=这一临床试验进行的怎么样, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=125.121.131.139, createdTime=Fri Jul 13 22:52:00 CST 2012, time=2012-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271344, encodeId=3bf012e13440c, content=<a href='/topic/show?id=a0ff950018f' target=_blank style='color:#2F92EE;'>#造血干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95001, encryptionId=a0ff950018f, topicName=造血干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e729101, createdName=huanbaofeng, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494466, encodeId=9ee21494466fd, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534992, encodeId=72331534992fb, content=<a href='/topic/show?id=f92a8602447' target=_blank style='color:#2F92EE;'>#自体造血干细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86024, encryptionId=f92a8602447, topicName=自体造血干细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02d712580056, createdName=dongjia2014, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=)]
    2012-07-08 俅侠

    #造血#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1900960, encodeId=69021900960b1, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 01 16:41:00 CST 2013, time=2013-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658742, encodeId=e7ec1658e4272, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Sun Oct 14 14:41:00 CST 2012, time=2012-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636518, encodeId=2505163651831, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Oct 20 23:41:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759151, encodeId=449f1e5915125, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Mar 29 10:41:00 CST 2013, time=2013-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4521, encodeId=a06c45212a, content=这一临床试验进行的怎么样, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=125.121.131.139, createdTime=Fri Jul 13 22:52:00 CST 2012, time=2012-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271344, encodeId=3bf012e13440c, content=<a href='/topic/show?id=a0ff950018f' target=_blank style='color:#2F92EE;'>#造血干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95001, encryptionId=a0ff950018f, topicName=造血干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e729101, createdName=huanbaofeng, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494466, encodeId=9ee21494466fd, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534992, encodeId=72331534992fb, content=<a href='/topic/show?id=f92a8602447' target=_blank style='color:#2F92EE;'>#自体造血干细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86024, encryptionId=f92a8602447, topicName=自体造血干细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02d712580056, createdName=dongjia2014, createdTime=Sun Jul 08 12:41:00 CST 2012, time=2012-07-08, status=1, ipAttribution=)]
    2012-07-08 dongjia2014

    #自体造血干细胞移植#

    0

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