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Eur Heart J:近红外光谱导出的LCBI可预测冠心病患者长期随访时不良心血管结局

2017-05-27 MedSci MedSci原创

近红外光谱(Near-infrared spectroscopy,NIRS)能量化冠状动脉内的胆固醇的脂质核心负荷指数(LCBI)。研究人员研究了在冠状动脉疾病(CAD)患者中长期随访心脏不良结局时,由近红外光谱导出的LCBI的预后情况。研究共纳入了2009-2013年间,在275例经冠状动脉造影确诊的急性冠脉综合征(ACS)和稳定型心绞痛患者的非梗死动脉的近红外光谱数据。通过独立的corelab

近红外光谱(Near-infrared spectroscopy,NIRS)能量化冠状动脉内的胆固醇的脂质核心负荷指数(LCBI)。研究人员研究了在冠状动脉疾病(CAD)患者中长期随访心脏不良结局时,由近红外光谱导出的LCBI的预后情况。

研究共纳入了2009-2013年间,在275例经冠状动脉造影确诊的急性冠脉综合征(ACS)和稳定型心绞痛患者的非梗死动脉的近红外光谱数据。通过独立的corelab对感兴趣区域(LCBIROI)和4mm或10mm的最大LCBI(MaxLCBI4mm and MaxLCBI10mm)的分析来量化LCBI。主要终点是主要的心脏不良事件(MACE),被定义为全因死亡、非致死性ACS或临时血运重建的复合发生。调整年龄、性别、临床危险因素和血管内超声确定的段斑块负荷后得出危险因素(HR)。

研究人员对患者中位随访4.1 年期间,79例患者(28.7%)出现了主要的心脏不良事件。较高的MaxLCBI4mm值与MACE高风险之间的联系具有统计学意义且独立连续。MaxLCBI4mm每100单位的增加都与MACE风险增加19%相关(HR 1.19,95%CI:1.07-1.32,P = 0.001)。排除目标损伤相关事件后,连续MaxLCBI4mm与MACE依然独立相关(HR 1.21,95% CI:1.08-1.35),同样在排除近红外光谱成像的冠状动脉段相关的不良事件后(HR 1.19,95% CI:1.06-1.34)。MaxLCBI10mm的结果与MaxLCBI4mm相似。

研究人员认为NIRS导出的LCBI与冠心病患者长期随访时的心脏不良预后相关,且独立于临床风险因素和斑块负荷。

原始出处:

Schuurman AS, Vroegindewey M,et al.Near-infrared spectroscopy-derived lipid core burden index predicts adverse cardiovascular outcome in patients with coronary artery disease during long-term follow-up.Eur Heart J. 2017 May 20. doi: 10.1093/eurheartj/ehx247. [Epub ahead of print]

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2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-31 为你把脉

    v哈哈很过分反反复复

    0

  5. 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createdName=gaoxiaoe, createdTime=Wed Nov 29 21:05:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804430, encodeId=cf00180443005, content=<a href='/topic/show?id=4047e71155a' target=_blank style='color:#2F92EE;'>#红外光谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77115, encryptionId=4047e71155a, topicName=红外光谱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Fri Jan 19 04:05:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204684, encodeId=10ab2046845e, content=v哈哈很过分反反复复, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed May 31 07:11:16 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204064, encodeId=b55a2040644c, content=vghhhhgggh, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon May 29 17:19:44 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269310, encodeId=b60d1269310d2, content=<a href='/topic/show?id=49d1518915a' target=_blank style='color:#2F92EE;'>#心血管结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51891, encryptionId=49d1518915a, topicName=心血管结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 为你把脉

    vghhhhgggh

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1967197, encodeId=94d6196e19725, content=<a href='/topic/show?id=87729e0451f' target=_blank style='color:#2F92EE;'>#长期随访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97045, encryptionId=87729e0451f, topicName=长期随访)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Sun Apr 15 21:05:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078245, encodeId=92f220e82456c, content=<a href='/topic/show?id=2fd29428e24' target=_blank style='color:#2F92EE;'>#近红外#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94287, encryptionId=2fd29428e24, topicName=近红外)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, 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2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, 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  7. 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2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562538, encodeId=cad41562538c7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203265, encodeId=276520326523, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 zhaojie88
  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1967197, encodeId=94d6196e19725, content=<a href='/topic/show?id=87729e0451f' target=_blank style='color:#2F92EE;'>#长期随访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97045, encryptionId=87729e0451f, topicName=长期随访)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Sun Apr 15 21:05:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078245, encodeId=92f220e82456c, content=<a href='/topic/show?id=2fd29428e24' target=_blank style='color:#2F92EE;'>#近红外#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94287, encryptionId=2fd29428e24, topicName=近红外)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, 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2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, 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    2017-05-29 slcumt
  10. 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    2017-05-27 wxl882001

    学习一下

    0

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