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Clinica Chimica Acta:糖化血红蛋白变异对2型糖尿病患者亚临床左室重构和功能障碍的影响

2020-04-12 MedSci原创 MedSci原创

血糖不稳定会给2型糖尿病(T2DM)患者带来不良预后的风险。本研究旨在探讨糖化血红蛋白变异性在预测T2DM患者亚临床左室重构和功能障碍方面是否比平均糖化血红蛋白变异性更能提供了额外的价值。

血糖不稳定会给2型糖尿病(T2DM)患者带来不良预后的风险。本研究旨在探讨糖化血红蛋白变异性在预测T2DM患者亚临床左室重构和功能障碍方面是否比平均糖化血红蛋白变异性更能提供了额外的价值。

本研究共招募466例心脏结构和功能正常的2型糖尿病患者,前瞻性随访中位数4.7 y。每季度测定糖化血红蛋白。计算HbA1c测量值的腹腔内均值和标准偏差(SD),并将SD-HbA1c作为HbA1c变异性的测量值。所有参与者在基线和随访后都接受了经胸超声心动图检查。

在多变量回归分析中,SD-HbA1c与左心室舒张末期直径,室间隔,左心室后壁,左心室质量指数,左心室射血分数,E / e'比和E / A比的年变化独立相关。 (P <0.001)。 根据平均HbA1c水平(<7.0%,7.0-7.5%和≥7.5%)进行的亚组分析进一步证实,无论平均糖化血红蛋白水平如何,SD-HbA1c与上述大多数参数相关。

本研究表明,HbA1c变异性增加了预测T2DM患者亚临床左心室重构和功能障碍的平均值。

原始出处:

Suhua Li,Zhenda Zheng,Impact of HbA1c variability on subclinical left ventricular remodeling and dysfunction in patients with type 2 diabetes mellitus

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    2020-09-24 windight
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    2020-04-13 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2020-04-13 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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