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Clin Gastroenterol Hepatol:及时抗生素治疗可降低上消化道出血肝硬化患者死亡率

2016-08-05 Mechront 译 MedSci原创

近期有研究表明,肝硬化患者上消化道出血住院治疗,使用抗生素可降低30%的30天死亡率。来自华盛顿大学的Lauren Beste博士和同事们对6451例上消化道出血(平均年龄为60.6岁)住院治疗的肝硬化患者进行了回顾性研究。他们收集了患者有关基线特征、病因、给予抗生素的信息、30天再入院率和死亡率等数据。研究者在入院前8小时和48小时内使用抗生素定义为研究中的“抗生素使用”。及时的抗生素管理发生在

近期有研究表明,肝硬化患者上消化道出血住院治疗,使用抗生素可降低30%的30天死亡率。

来自华盛顿大学的Lauren Beste博士和同事们对6451例上消化道出血(平均年龄为60.6岁)住院治疗的肝硬化患者进行了回顾性研究。他们收集了患者有关基线特征、病因、给予抗生素的信息、30天再入院率和死亡率等数据。研究者在入院前8小时和48小时内使用抗生素定义为研究中的“抗生素使用”。

及时的抗生素管理发生在48.6%的患者治疗中,从2005年的30.6%增加到2013年的58.1%。腹水、终末期肝病、食管静脉曲张破裂出血和使用奥曲肽或静脉应用质子泵抑制剂进行管理,与抗生素使用增加有关;而黑人和非酒精性脂肪性肝病患者与抗生素使用的减少有关。此外,及时使用抗生素可降低30%的30天死亡率(aOR=0.7; 95% CI, 0.52-0.93; P = .012)。

研究人员写道,这些数据表明,临床不明显的肝功能衰竭的患者,如那些没有腹水或肝性脑病的患者,不太可能接受抗生素治疗。

研究表明,上消化道出血住院治疗的肝硬化患者,使用抗生素可降低30%的30天死亡率。

原始出处:

Antibiotic use associated with reduced mortality in UGIB patients.Healio.August 4, 2016

Moon AW, et al. Use of Antibiotics Among Patients With Cirrhosis and Upper Gastrointestinal Bleeding Is Associated With Reduced Mortality.Clin Gastroenterol Hepatol. 2016;doi:10.1016/j.cgh.2016.05.040.

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    2016-10-18 许安
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encodeId=8b9a9659eda, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 07 07:16:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-10-30 WEIXIN34ae6700

    对于目前静脉曲张破裂出血就要求预防抗感染治疗,这与指南是一致的~

    0

  6. 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encodeId=8b9a9659eda, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 07 07:16:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-09-23 1e10c84am36(暂无匿称)

    深度好文,值得学习

    0

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  8. 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encodeId=8b9a9659eda, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 07 07:16:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  9. 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encodeId=8b9a9659eda, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 07 07:16:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-08-11 木水晶

    这个结论目前能用到临床吗?

    0

  10. 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likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 16:48:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97645, encodeId=95a49e645eb, content=这个结论目前能用到临床吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Thu Aug 11 22:33:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96597, encodeId=8b9a9659eda, content=学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 07 07:16:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-08-07 刘煜

    学习。

    0

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