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Lancet Oncol：分子生物学标记有助于CNS PNETs患者治疗

2012-08-16 丁香园 丁香园

分子生物学标记儿童中枢神经系统原始神经外胚层脑瘤CNSPNETs
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                             CNS PNETs患儿不同亚组的临床和分子生物学特征 儿童中枢神

            

                CNS PNETs患儿不同亚组的临床和分子生物学特征

儿童中枢神经系统原始神经外胚层脑瘤（PNETs）是一种侵袭程度很高的肿瘤，目前对其分子生物学特征及最优治疗方法我们还知之甚少。来自诺丁汉大学儿童脑肿瘤研究中心的Grundy教授所带领的研究团队就此进行研究，研究结果已经发表在Lancet Oncol上。在该研究中，研究者就该罕见的肿瘤进行研究以确定其分子标记来指导临床对该疾病的治疗。

研究者共纳入142名原发半球CNS PNET患者，这些患者来自于9个国家20个机构，并研究了51个样本的转录谱和77个样本的拷贝数。研究者们分析并确定肿瘤亚组和组内特异性生物标记，并应用免疫组化技术和基因表达分析以验证和评估亚组标记的临床显著性。

研究者们发现了CNS PNETs由于细胞谱标志LIN28和OLIG2表达不同分成三个亚组。在3组间，组1的患者大多为女性，并且在确诊时年龄最小，其生存时间较组2和组3而言也是最短的。而组3的患者在确诊时出现转移的比率最高。

研究结论指出LIN28和OLIG2作为CNS PNET诊断和预后的分子标记具有潜在应用价值，但仍需在未来的临床研究中进行进一步评估。

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    2012-10-27 howi

    #Lancet#

    0

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    2012-12-17 lg.zhao

    #CNS#

    0

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    2012-08-17 zhouqu_8

    #PNETs#

    0

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    2012-10-19 canlab

    #NET#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1827446, encodeId=e746182e446b8, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 27 04:26:00 CST 2012, time=2012-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914214, encodeId=2a1f1914214b5, content=<a href='/topic/show?id=4b8349356f' target=_blank style='color:#2F92EE;'>#CNS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4935, encryptionId=4b8349356f, topicName=CNS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Dec 17 23:26:00 CST 2012, time=2012-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791433, encodeId=17dc1e91433cc, content=<a href='/topic/show?id=801314432c4' target=_blank style='color:#2F92EE;'>#PNETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14432, encryptionId=801314432c4, topicName=PNETs)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 17 08:26:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733606, encodeId=4c111e3360602, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Oct 19 21:26:00 CST 2012, time=2012-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937592, encodeId=9a6c193e592b9, content=<a href='/topic/show?id=73ec316486c' target=_blank style='color:#2F92EE;'>#分子生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31648, encryptionId=73ec316486c, topicName=分子生物学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sat Jun 08 15:26:00 CST 2013, time=2013-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864380, encodeId=840b1864380ed, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Nov 11 07:26:00 CST 2012, time=2012-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553770, encodeId=034f1553e709c, content=<a href='/topic/show?id=5332126e5b5' target=_blank style='color:#2F92EE;'>#NETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12675, encryptionId=5332126e5b5, topicName=NETs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a16414422875, createdName=wincls, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617738, encodeId=179b161e73806, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2013-06-08 bshuang

    #分子生物学#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1827446, encodeId=e746182e446b8, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 27 04:26:00 CST 2012, time=2012-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914214, encodeId=2a1f1914214b5, content=<a href='/topic/show?id=4b8349356f' target=_blank style='color:#2F92EE;'>#CNS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4935, encryptionId=4b8349356f, topicName=CNS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Dec 17 23:26:00 CST 2012, time=2012-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791433, encodeId=17dc1e91433cc, content=<a href='/topic/show?id=801314432c4' target=_blank style='color:#2F92EE;'>#PNETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14432, encryptionId=801314432c4, topicName=PNETs)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 17 08:26:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733606, encodeId=4c111e3360602, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Oct 19 21:26:00 CST 2012, time=2012-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937592, encodeId=9a6c193e592b9, content=<a href='/topic/show?id=73ec316486c' target=_blank style='color:#2F92EE;'>#分子生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31648, encryptionId=73ec316486c, topicName=分子生物学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sat Jun 08 15:26:00 CST 2013, time=2013-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864380, encodeId=840b1864380ed, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Nov 11 07:26:00 CST 2012, time=2012-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553770, encodeId=034f1553e709c, content=<a href='/topic/show?id=5332126e5b5' target=_blank style='color:#2F92EE;'>#NETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12675, encryptionId=5332126e5b5, topicName=NETs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a16414422875, createdName=wincls, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617738, encodeId=179b161e73806, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-11-11 minlingfeng

    #Oncol#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1827446, encodeId=e746182e446b8, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 27 04:26:00 CST 2012, time=2012-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914214, encodeId=2a1f1914214b5, content=<a href='/topic/show?id=4b8349356f' target=_blank style='color:#2F92EE;'>#CNS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4935, encryptionId=4b8349356f, topicName=CNS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Dec 17 23:26:00 CST 2012, time=2012-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791433, encodeId=17dc1e91433cc, content=<a href='/topic/show?id=801314432c4' target=_blank style='color:#2F92EE;'>#PNETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14432, encryptionId=801314432c4, topicName=PNETs)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 17 08:26:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733606, encodeId=4c111e3360602, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Oct 19 21:26:00 CST 2012, time=2012-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937592, encodeId=9a6c193e592b9, content=<a href='/topic/show?id=73ec316486c' target=_blank style='color:#2F92EE;'>#分子生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31648, encryptionId=73ec316486c, topicName=分子生物学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sat Jun 08 15:26:00 CST 2013, time=2013-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864380, encodeId=840b1864380ed, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Nov 11 07:26:00 CST 2012, time=2012-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553770, encodeId=034f1553e709c, content=<a href='/topic/show?id=5332126e5b5' target=_blank style='color:#2F92EE;'>#NETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12675, encryptionId=5332126e5b5, topicName=NETs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a16414422875, createdName=wincls, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617738, encodeId=179b161e73806, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-08-18 wincls

    #NETs#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1827446, encodeId=e746182e446b8, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 27 04:26:00 CST 2012, time=2012-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914214, encodeId=2a1f1914214b5, content=<a href='/topic/show?id=4b8349356f' target=_blank style='color:#2F92EE;'>#CNS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4935, encryptionId=4b8349356f, topicName=CNS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Dec 17 23:26:00 CST 2012, time=2012-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1791433, encodeId=17dc1e91433cc, content=<a href='/topic/show?id=801314432c4' target=_blank style='color:#2F92EE;'>#PNETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14432, encryptionId=801314432c4, topicName=PNETs)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Aug 17 08:26:00 CST 2012, time=2012-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733606, encodeId=4c111e3360602, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Oct 19 21:26:00 CST 2012, time=2012-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937592, encodeId=9a6c193e592b9, content=<a href='/topic/show?id=73ec316486c' target=_blank style='color:#2F92EE;'>#分子生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31648, encryptionId=73ec316486c, topicName=分子生物学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sat Jun 08 15:26:00 CST 2013, time=2013-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864380, encodeId=840b1864380ed, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Nov 11 07:26:00 CST 2012, time=2012-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553770, encodeId=034f1553e709c, content=<a href='/topic/show?id=5332126e5b5' target=_blank style='color:#2F92EE;'>#NETs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12675, encryptionId=5332126e5b5, topicName=NETs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a16414422875, createdName=wincls, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617738, encodeId=179b161e73806, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Sat Aug 18 02:26:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-08-18 12498c32m74暂无昵称

    #生物学#

    0

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