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J Exp Clin Cancer Res：低强度脉冲超声对乳腺癌细胞体外诱导破骨细胞形成的抑制作用

2018-09-10 MedSci MedSci原创

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骨组织是乳腺转移的主要部位之一，诊断为晚期乳腺癌的患者常会发生骨转移，其特征为严重的溶骨性病变，严重影响其生活质量。低强度脉冲超声（LIPUS）是一种能够调节癌症和健康细胞中各种分子通路的机械能。本研究旨在评估LIPUS调节乳腺癌细胞溶骨能力的能力。 采用两种不同的方法：a）用LIPUS处理或未处理的MDA-MB-231细胞系获得的间接方法-条件培养基用于诱导小鼠巨噬细胞Raw264.7细胞

骨组织是乳腺转移的主要部位之一，诊断为晚期乳腺癌的患者常会发生骨转移，其特征为严重的溶骨性病变，严重影响其生活质量。低强度脉冲超声（LIPUS）是一种能够调节癌症和健康细胞中各种分子通路的机械能。本研究旨在评估LIPUS调节乳腺癌细胞溶骨能力的能力。

采用两种不同的方法：a）用LIPUS处理或未处理的MDA-MB-231细胞系获得的间接方法-条件培养基用于诱导小鼠巨噬细胞Raw264.7细胞系的破骨细胞分化；b）直接法-MDA-MB-231与Raw264.7细胞共培养，用LIPUS处理或不处理。

LIPUS治疗损害MDA-MB-231细胞依赖性破骨细胞分化并产生破骨细胞标志物，如组织蛋白酶K，基质金属蛋白酶9和酒石酸抗性酸性磷酸酶的减少，表明其在骨转移管理中作为有效且安全的佐剂的作用。

LIPUS治疗可以是骨溶解性骨转移中的良好且安全的治疗佐剂，不仅可诱导骨再生，而且可用于减少骨质溶解。

原始出处：

Valeria Carina, Viviana Costa, et al., Inhibitory effects of low intensity pulsed ultrasound on osteoclastogenesis induced in vitro by breast cancer cells. J Exp Clin Cancer Res. 2018; 37: 197.

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    2018-10-08 124987a0m73(暂无昵称)

    #抑制作用#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1635447, encodeId=b80e163544eaa, content=<a href='/topic/show?id=b099549160a' target=_blank style='color:#2F92EE;'>#抑制作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54916, encryptionId=b099549160a, topicName=抑制作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6cd322475383, createdName=124987a0m73(暂无昵称), createdTime=Mon Oct 08 20:52:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252537, encodeId=f910125253e72, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Wed Sep 12 13:52:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309992, encodeId=9e491309992ab, content=<a href='/topic/show?id=2830e349460' target=_blank style='color:#2F92EE;'>#破骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73494, encryptionId=2830e349460, topicName=破骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Wed Sep 12 13:52:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495075, encodeId=307614950e550, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 13:52:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344427, encodeId=0ade34442e41, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Sep 10 23:10:36 CST 2018, time=2018-09-10, status=1, ipAttribution=)]
    2018-09-12 yxch36

    #癌细胞#

    0

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    2018-09-12 caobinglei8079

    #破骨细胞#

    0

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    2018-09-12 jj000004

    #骨细胞#

    0

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    2018-09-10 天地飞扬

    了解一下，谢谢分享！

    0

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