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BMJ Open Diabetes Res Care:脂联素预测前驱糖尿病(POP-ABC)

2016-03-28 Seven L MedSci原创

近期发表在BMJ Open Diabetes Res Care的研究称,对于父母伴有2型糖尿病的健康白人和黑人,脂联素水平可作为他们前驱糖尿病强有力的风险标志物。田纳西大学健康科学中心的Samuel Dagogo-Jack博士和同事对151名白人和182名黑人(平均年龄44.2岁)进行了一项研究,评估基线脂联素水平与前驱糖尿病发生率的关系。研究数据显示,纳入研究时所有参与者脂联素水平为3.14 µ

近期发表在BMJ Open Diabetes Res Care的研究称,对于父母伴有2型糖尿病的健康白人和黑人,脂联素水平可作为他们前驱糖尿病强有力的风险标志物。

田纳西大学健康科学中心的Samuel Dagogo-Jack博士和同事对151名白人和182名黑人(平均年龄44.2岁)进行了一项研究,评估基线脂联素水平与前驱糖尿病发生率的关系。

研究数据显示,纳入研究时所有参与者脂联素水平为3.14 µg/mL-45.8 µg/mL,中位数为7.96 µg/mL,平均数为9.41 µg/mL。脂联素水平女性高于男性(10.3 µg/mL vs. 7.27 µg/mL; P < .0001),白人高于黑人(10.7 µg/mL vs. 8.34 µg/mL; P < .0001)。

平均随访时间的2.6年期间,有33%的参与者进展为前驱糖尿病(n=100)或糖尿病(n=10),这类患者纳入研究时的平均脂联素水平更低(相较于血糖正常的参与者 8.37 µg/mL vs 9.92 µg/mL;P=0.012)。此外研究者发现,脂联素和进展为前驱糖尿病/糖尿病呈负相关(OR = 0.48;95% CI,0.27-0.86)。基线脂联素水平每增加1个标准差,进展为前驱糖尿病风险降低40%。

作者写道:“对于父母有2型糖尿病的健康白人和黑人而言,基线脂联素水平与前驱糖尿病呈负相关。虽然脂联素水平存在性别、种族差异,但两者间的联系仍存在。所以无论性别、种族,提高脂联素水平或许可以增强糖代谢异常的保护能力。”

原始出处:

Jiang Y, et al. Adiponectin levels predict prediabetes risk: the Pathobiology of Prediabetes in A Biracial Cohort (POP-ABC) study.BMJ Open Diabetes Res Care. 2016;doi:10.1136/bmjdrc-2016-000194.

Adiponectin levels may predict incident prediabetes risk.Healio.Mar 18, 2016

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    2016-10-21 gaoxiaoe
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1777053, encodeId=2b261e770534f, content=<a href='/topic/show?id=45ae1e1830' target=_blank style='color:#2F92EE;'>#ABC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1718, encryptionId=45ae1e1830, topicName=ABC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54039078223, createdName=cmj21wellington, createdTime=Mon Nov 28 04:07:00 CST 2016, time=2016-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637301, encodeId=f442163e301b2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Sep 23 12:07:00 CST 2016, time=2016-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847946, encodeId=1df4184e94645, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Oct 21 14:07:00 CST 2016, time=2016-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759654, encodeId=bbb71e5965436, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jun 07 23:07:00 CST 2016, time=2016-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726061, encodeId=27bf1e2606197, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Dec 02 21:07:00 CST 2016, time=2016-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901364, encodeId=77b9190136413, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Sep 29 12:07:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=80689, encodeId=2c1c806897f, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Apr 22 16:55:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=80691, encodeId=d9ab8069127, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Apr 22 16:55:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=80690, encodeId=a5a4806903b, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Apr 22 16:55:00 CST 2016, time=2016-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=80688, encodeId=edbe8068839, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Apr 22 16:55:00 CST 2016, time=2016-04-22, status=1, ipAttribution=)]
    2016-12-02 feather89
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    2016-04-22 忠诚向上

    值得学习

    0

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    2016-04-22 忠诚向上

    值得学习

    0

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    2016-04-22 忠诚向上

    值得学习

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    2016-04-22 忠诚向上

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