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NEJM:Vericiguat可降低高危心衰患者不良预后风险

2020-05-14 MedSci原创 MedSci原创

对于高危心衰患者,接受vericiguat治疗后,患者因心血管原因死亡或心衰住院率降低

Vericiguat是一种新型口服可溶性鸟苷酸环化酶激动剂,近日研究人员考察了其对住院或接受静脉利尿剂的心力衰竭和射血分数降低患者的治疗效果。
 
本次研究为III期临床研究,5050名慢性心力衰竭且射血分数低于45%的患者参与研究,除接受指南药物治疗外,随机服用vericiguat(目标剂量,每天10毫克)或安慰剂。研究的主要结果是心血管原因死亡或首次心力衰竭住院。
 
在10.8个月的中位随访期间,Vericiguat组2526名患者中有897名(35.5%)发生了主要结果事件,安慰剂组2524名患者中有972名(38.5%)发生了主要结果事件(危险比为0.90)。Vericiguat组共有691名患者(27.4%)和安慰剂组747名患者(29.6%)因心力衰竭住院(危险比为0.90)。Vericiguat组414例(16.4%)和安慰剂组441例(17.5%)因心血管原因死亡(危险比0.93)。因任何原因或因心力衰竭住院而死亡的组合终点事件,Vericiguat组的957名患者(37.9%),安慰剂组的1032名患者(40.9%,危险比:0.90)。Vericiguat组和安慰剂组分别有9.1%和7.9%的患者出现症状性低血压,分别有4.0%和3.5%的患者出现晕厥。
 
研究认为,对于高危心衰患者,接受vericiguat治疗后,患者因心血管原因死亡或心衰住院率降低。
 
原始出处:
 
Paul W. Armstrong et al. Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med, May 14, 2020.

 

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    2021-02-17 健康达人

    鸟苷酸环化酶C,能治疗#便秘#,本药能治#心衰#

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    2020-05-14 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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