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BMJ:早起不赖床有助于降低乳腺癌风险

2019-06-28 MedSci MedSci原创

研究认为,早起人群的乳腺癌风险较低,过长的睡眠时间可能导致乳腺癌风险增加

近日研究人员检查了睡眠特征对乳腺癌风险的影响。

2个队列女性参与研究,UK Biobank队列包含156848名妇女,7784例乳腺癌诊断,BCAC队列包含122 977例乳腺癌病例和105 974名对照者。考察参与者自我报告的入眠时间类型(早晨或晚上)、失眠症状和多变量回归中的睡眠持续时间,以及与这些睡眠特征相关的遗传变体。

UK Biobank队列中,早起偏好与乳腺癌呈负相关(HR=0.95),而睡眠时间和失眠症状与乳腺癌风险无关。通过对341个与入眠时间相关的单核苷酸多态性(SNPS)、91个与睡眠时间相关的SNPS和57个与失眠症状相关的SNPS分析可解释早起偏好对乳腺癌的保护作用。BCAC研究支持早起偏好(OR=0.88)和睡眠时间延长(每增加1小时OR=1.19)对乳腺癌风险的影响。

研究认为,早起人群的乳腺癌风险较低,过长的睡眠时间可能导致乳腺癌风险增加。

原始出处:


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    2019-09-09 gaoxiaoe
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    2020-04-14 sjq027

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