Cell Metab：父亲的饮食习惯对未来宝宝的健康很重要

2015-12-06 zhaoshuang 译 MedSci原创

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有许多研究都证明，孕前父母的生活方式、居住环境会对孩子的健康产生影响。最近发表在Cell Metabolism上的一项研究对其中的原因进行了阐述说明。

研究者对13名健壮清瘦的男性和10名肥胖男性的精子细胞进行对比，发现二者拥有不同的表现的遗传标记，这些遗传标记表达出来则可以改变下一代的饮食习惯。

此外研究者还对6名胃分流术（一种减肥的有效干预措施）后的人进行了跟踪调查，来研究该手术是如何影响包含在精子细胞中的这些遗传信息。他们观察到了从手术到术后一年，这些观察对象的精子细胞DNA发生了大概4000次结构性改变。

他们的研究结果表明减肥会使饮食习惯改变，并且父亲的饮食习惯会对孩子的健康产生影响。

研究负责人Romain Barrès提出，根据流行病学观察发现，短时间内饮食营养压力紧张，比如一代人面临饥荒，会使他们的后代出现糖尿病的几率会增加。

子孙的健康会因为祖辈、父辈配子（精子或卵子）的特殊遗传表现（DNA蛋白质的化学添加、DNA甲基结构改变等）而受到影响。

通过检测小RNA表达的差异和DNA甲基化模式，研究者证明了减肥可以改变精子细胞内的遗传信息，换句话说，父亲精子细胞传递的遗传信息可以影响胚胎的形成，最终影响孩子的生理特性。不管母亲的体重如何，只要父亲肥胖，那么小孩在以后的生活中会更容易肥胖。

因此孕前生活方式尤其是饮食习惯非常重要。父母的饮食习惯以及锻炼情况都会对孩子的健康和成长产生重要影响。

原始出处：

What your father ate before you were born could influence your health.Sciencedaily.December 4, 2015

Romain Barrès.Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metabolism.Dec.2015

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2016-09-21 维他命

#CEL#

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2016-02-25 zhaozhouchifen

#Cell#

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2016-05-13 一闲

#MET#

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2016-01-09 guojianrong

#Meta#

59 0
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2016-02-16 mengli1984

父母的饮食习惯以及锻炼情况都会对孩子的健康和成长产生重要影响。

194 0
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2016-01-28 1de3b290m83(暂无匿称)

做好父亲

160 0
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2015-12-25 stfoxst

#饮食习惯#

62 0
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objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Wed Jan 20 09:34:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48865, encodeId=106e4886509, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:24:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48866, encodeId=35b148866a5, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:24:00 CST 2015, time=2015-12-27, status=1, ipAttribution=)]
2016-01-20 ssummer

有帮助！

117 0
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encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Jan 09 13:15:00 CST 2016, time=2016-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64479, encodeId=8be1644e93f, content=父母的饮食习惯以及锻炼情况都会对孩子的健康和成长产生重要影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=194, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/14/d0501100fdfe783cab0715811e01c133.jpg, createdBy=51ed1602754, createdName=mengli1984, createdTime=Tue Feb 16 20:26:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61694, encodeId=eb9d6169425, content=做好父亲, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Thu Jan 28 03:01:00 CST 2016, time=2016-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1927061, encodeId=aa67192e06134, content=<a href='/topic/show?id=629c1012246f' target=_blank style='color:#2F92EE;'>#饮食习惯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101224, encryptionId=629c1012246f, topicName=饮食习惯)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Fri Dec 25 20:15:00 CST 2015, time=2015-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58494, encodeId=988f58494b5, content=有帮助！, beContent=null, 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2015-12-27 hixiaoluo

好文章，值得收藏

137 0
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2015-12-27 hixiaoluo

好文章，值得收藏

167 0

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