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Clinical Nutrition:素食饮食可减少与支链氨基酸有关的中性粒细胞,单核细胞和血小板数量

2020-11-15 MedSci原创 MedSci原创

有研究显示素食主义者(VD)改善了类风湿关节炎(RA)患者的炎症活性,其机制尚不清楚。本项研究探究了健康志愿者食用VD与富含肉类饮食(MD)相比对炎症标志物的影响。

背景及目的:

有研究显示素食主义者(VD)改善了类风湿关节炎(RA)患者的炎症活性,其机制尚不清楚。本项研究探究了健康志愿者食用VD与富含肉类饮食(MD)相比对炎症标志物的影响。

 

 

 

方法

在一周控制混合饮食的治疗前阶段,将53名健康,杂食性受试者随机分为4个星期的受控VD(n = 26)或MD(n = 27)饮食组。主要观察结局是免疫球蛋白的唾液酸化程度,调节性T细胞的百分比和白介素10(IL10)的水平。次要指标是RA疾病活动程度和氨基酸血清水平以及粒细胞和单核细胞集落刺激因子(GM-CSF)血清水平。

 

 

 

结果

在VD组中,白血球,中性粒细胞,单核细胞和血小板的总计数减少,与MD组相比,四周后它们数量显着降低(白细胞p = 0.003,中性粒细胞p = 0.001,单核细胞p = 0.032,血小板p = 0.004 )。白细胞,嗜中性粒细胞,单核细胞和血小板相互关联,并且同样符合支链氨基酸的血清水平,与MD组相比,VD的血清水平明显降低。各组之间的主要参数没有差异,两组的BMI保持稳定。

 

 

 

结论

受控VD的四个星期显著降低中性粒细胞,单核细胞和血小板的数量,但不影响淋巴细胞的数量或功能。

 

 

原始出处:

Ann-KathrinLederer. Et al. Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – A randomized, controlled trial. Clinical Nutrition.2020.

 

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    2022-01-28 萌宝嘟嘟

    谢谢分享,好东西!

    0

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    2020-11-17 zll0628

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