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JAMA:正念减压治疗能否帮助创伤后应激障碍患者走出阴影?

2015-08-13 张森 译 MedSci原创

正念减压(MBSR)由美国麻省大学医学中心的Jon  Kabatzinn博士所创立,用于辅助(而非取代)一般的医疗行为,参与疗程的病患通常各自患有不同的生理或心理疾病,MBSR旨在教导病患运用自己内在的身心力量,为自己的身心健康积极地做一些他人无法替代的事——培育正念。对于存在创伤后应激障碍(PTSD)的退伍军人来说,其对现存循证治疗的依从性较差,以正念为基础的干预措施也许更易被其接受。

正念减压(MBSR)由美国麻省大学医学中心的Jon  Kabatzinn博士所创立,用于辅助(而非取代)一般的医疗行为,参与疗程的病患通常各自患有不同的生理或心理疾病,MBSR旨在教导病患运用自己内在的身心力量,为自己的身心健康积极地做一些他人无法替代的事——培育正念。对于存在创伤后应激障碍(PTSD)的退伍军人来说,其对现存循证治疗的依从性较差,以正念为基础的干预措施也许更易被其接受。

本研究为一项随机临床试验,于2012.03-2013.12从明尼阿波利斯退伍军人事务部医疗中心招募116名存在创伤后应激障碍的退伍军人。

退伍军人被随机分为正念减压治疗组(n=58):由9次会话组成(每周2.5小时组间会话持续8周,及一整天静思)教导病人以无偏见,接受的方式致力于当下;或者以现在为中心的团队治疗组(n=58):专注于目前的生活问题的一个主动控制情境,每周1.5小时组间会话持续9周.

使用PTSD检测表(范围:17-85;分数越高表示越严重)在基线,第3,6,9及17周对主要终点,随着时间的推移PTSD症状严重程度的变化进行评估。使用临床医师专用PTSD量表连同抑郁症状、生活质量及正念等方面的改善对包括PTSD诊断,症状严重程度在内的次要终点进行评估。

在治疗期间,正念减压治疗组的退伍军人在自我报道PTSD症状严重程度中显示出更显著的改善(平均PTSD 检测量表分数的改变:63.6- 55.7 (正念减压治疗)vs 58.8 - 55.8(以现在为中心的团队治疗);组间差异,4.95;95% CI,1.92-7.99;P=.002),并且在2个月的随访中(平均分数的改变:63.6 - 54.4 (正念减压治疗)vs 58.8 to 56.0(以现在为中心的团队治疗);组间差异,6.44; 95% CI,3.34-9.53,P<.001). 尽管正念减压治疗组的退伍军人在自我报道PTSD症状严重性上有更显著的临床意义上的改善 (48.9%(正念减压治疗) vs 28.1%(以现在为中心的团队治疗);组间差异, 20.9%; 95% CI, 2.2%-39.5%;P=0.03),在2个月的随访中, 则不存在排除 PTSD 诊断的可能 (53.3%(正念减压治疗) vs 47.3%(以现在为中心的团队治疗);组间差异,6.0%;95%CI,−14.1% to 26.2%;P=0.55).

本研究表明:与以现在为中心的团队治疗相比,正念减压治疗能够更显著的减弱PTSD症状的严重程度。然而,在平均改善幅度上仅存在适度的影响。

原始出处:

Melissa A. Polusny; Christopher R. Erbes; Paul Thuras,; Amy Moran; Greg J. Lamberty; Rose C. Collins; John L. Rodman; Kelvin O. Lim;Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans A Randomized Clinical Trial JAMA. 2015;314(5):456-465

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  1. [GetPortalCommentsPageByObjectIdResponse(id=42745, encodeId=749042e4530, content=感觉很难实行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754a1652870, createdName=1ddcfa8bm07(暂无匿称), createdTime=Sat Nov 07 16:17:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335080, encodeId=61c41335080f5, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445108, encodeId=b3e31445108c5, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35597, encodeId=64b53559eca, content=国外这种研究也能够上JAMA, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:18:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35558, encodeId=d81835558b2, content=符合当今的医学理念哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10a41638418, createdName=jdklsj, createdTime=Fri Aug 14 13:02:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
    2015-11-07 1ddcfa8bm07(暂无匿称)

    感觉很难实行啊

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=42745, encodeId=749042e4530, content=感觉很难实行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754a1652870, createdName=1ddcfa8bm07(暂无匿称), createdTime=Sat Nov 07 16:17:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335080, encodeId=61c41335080f5, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445108, encodeId=b3e31445108c5, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35597, encodeId=64b53559eca, content=国外这种研究也能够上JAMA, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:18:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35558, encodeId=d81835558b2, content=符合当今的医学理念哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10a41638418, createdName=jdklsj, createdTime=Fri Aug 14 13:02:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=42745, encodeId=749042e4530, content=感觉很难实行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754a1652870, createdName=1ddcfa8bm07(暂无匿称), createdTime=Sat Nov 07 16:17:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335080, encodeId=61c41335080f5, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445108, encodeId=b3e31445108c5, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35597, encodeId=64b53559eca, content=国外这种研究也能够上JAMA, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:18:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35558, encodeId=d81835558b2, content=符合当今的医学理念哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10a41638418, createdName=jdklsj, createdTime=Fri Aug 14 13:02:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=42745, encodeId=749042e4530, content=感觉很难实行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754a1652870, createdName=1ddcfa8bm07(暂无匿称), createdTime=Sat Nov 07 16:17:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335080, encodeId=61c41335080f5, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445108, encodeId=b3e31445108c5, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35597, encodeId=64b53559eca, content=国外这种研究也能够上JAMA, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:18:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35558, encodeId=d81835558b2, content=符合当今的医学理念哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10a41638418, createdName=jdklsj, createdTime=Fri Aug 14 13:02:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
    2015-08-14 medcardio

    国外这种研究也能够上JAMA

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=42745, encodeId=749042e4530, content=感觉很难实行啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754a1652870, createdName=1ddcfa8bm07(暂无匿称), createdTime=Sat Nov 07 16:17:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335080, encodeId=61c41335080f5, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445108, encodeId=b3e31445108c5, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Aug 15 14:08:00 CST 2015, time=2015-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35597, encodeId=64b53559eca, content=国外这种研究也能够上JAMA, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:18:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35558, encodeId=d81835558b2, content=符合当今的医学理念哦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10a41638418, createdName=jdklsj, createdTime=Fri Aug 14 13:02:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
    2015-08-14 jdklsj

    符合当今的医学理念哦!

    0

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