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AHA 2014:缺氧和低血压对外伤性脑损伤有协同负面效应

2014-11-20 高晓方 译 医学论坛网

AHA 2014科学年会的一项报告表明,院前缺氧和低血压可对外伤性脑损伤(TBI)患者产生协同负面效应,导致死亡风险相对于单一因素显著升高3倍以上。14 此项研究共纳入9194例中重度TBI患者,并以氧饱和度<90%定义缺氧,以收缩压<90 mmHg定义低血压。对年龄、性别、种族、付款来源和创伤治疗中心等混淆因素进行校正之后,利用比值比(OR)评估死亡率与缺氧和/或低血压之间

AHA 2014科学年会的一项报告表明,院前缺氧低血压可对外伤性脑损伤(TBI)患者产生协同负面效应,导致死亡风险相对于单一因素显著升高3倍以上。14

此项研究共纳入9194例中重度TBI患者,并以氧饱和度<90%定义缺氧,以收缩压<90 mmHg定义低血压。对年龄、性别、种族、付款来源和创伤治疗中心等混淆因素进行校正之后,利用比值比(OR)评估死亡率与缺氧和/或低血压之间的相关性。同时将对TBI治疗指南实施前后的诊治情况加以评估。

结果显示,大部分患者(88.2%)既无缺氧也无低血压,同时伴有缺氧和高血压的患者为131例(1.4%),仅有缺氧的患者和仅有低血压的患者分别为535例(5.8%)和419例(4.6%)。院前缺氧和低血压均与死亡率显著升高具有相关性。仅缺氧或低血压患者的死亡率分别为29.7%(OR 4.1)和21.8%(OR 3.0),缺氧联合低血压患者则为50.6%(OR13.8)。TBI患者的理想血压为144 mmHg。积极治疗缺氧和低血压的前瞻性干预试验仍在进行之中。

挪威奥斯陆大学医院Olasveengen博士表示,缺氧和低血压与TBI患者不良转归的相关性并不令人吃惊,未来需进一步评估缺氧/低血压能够在何种程度上作为严重损伤患者的标志物,以及其是否代表了改善患者转归的真正干预时机。

英文链接:Hypoxia, Hypotension 'Deadly Combo' in TBI


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    2014-11-22 zhaohui6731
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2014年美国心脏学会(AHA)科学年会将于11月16日至19日在美国芝加哥隆重举行。今年的会议注重讨论环节,不仅发布最新临床试验,还增强了互动性,形式多样。AHA2014大会主席Robert Harrington博士在欢迎辞中写道,本届大会将围绕心血管领域的7个核心方面展开,覆盖了“基础、转化、临床以及人口科学”四个方面。也将一如既往地快速、全面报道本次学术盛会,敬请关注专题报道。

郭艺芳点评:强效降胆固醇:大剂量他汀还是常规剂量他汀联合依折麦布?(IMPROVE-IT研究)

2014年AHA年会期间揭晓了IMPROVE-IT研究结果。近年来,此研究一直受到广泛期待。之所以如此,是因为这项研究或可回答两个至关重要的问题:(1)降胆固醇是硬道理还是他汀是硬道理?已有充分证据显示,应用他汀降低胆固醇水平可以显著降低心血管病患者及其高危人群不良心血管事件的发生率。但应用其他药物降低胆固醇水平是否产生同样的获益尚不清楚。(2)当LDL-C处于较低水平时继续降低其水平可否进一步获

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