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Diabetes:依帕列净与健康人和2型糖尿病患者的肾脏葡萄糖转运动力学分析!

2017-04-23 xing.T MedSci原创

总而言之,钠葡萄糖共转运体2的抑制剂依帕列净可以降低TmG和葡萄糖从尿液中溢出的阈值,无论是2型糖尿病患者,还是非糖尿病患者。

近日,糖尿病领域权威杂志Diabetes上发表了一篇研究文章,研究人员采用阶梯高葡萄糖钳夹来测量肾脏葡萄糖重吸收,该研究的参与者包括了15例2型糖尿病患者和15名非糖尿病患者,研究人员在对这些参与者给予钠葡萄糖共转运体2抑制剂依帕列净治疗2天后和更长时间(14天)测量了参与者的肾脏葡萄糖重吸收。

在研究之初,2型糖尿病患者有显著更大的最大的肾葡萄糖转运(TmG),与非糖尿病患者相比(459±53 vs. 337±25毫克/分钟,P<0.05)。在糖尿病和非糖尿病个体接受依帕列净治疗48小时后 TmG分别减少了44 7%±7%和53 6%±6%(P均<0.001)。在治疗14天后,两组TmG是可以被依帕列净治疗进一步减少(分别为65±5%和75±3%)。研究人员发现采用依帕列净治疗可以显著降低血浆中葡萄糖浓度阈值,使葡萄糖从尿液中溢出,在2型糖尿病患者和非糖尿病个体中均小于40毫克/分升,该值远远低于正常空腹血浆中的葡萄糖浓度。

总而言之,钠葡萄糖共转运体2的抑制剂依帕列净可以降低TmG和葡萄糖从尿液中溢出的阈值,无论是2型糖尿病患者,还是非糖尿病患者。

原始出处:

Hussein Al-Jobori, et al. Empagliflozin and Kinetics of Renal Glucose Transport in Healthy and Type 2 Diabetic Individuals.Diabetes 2017 Apr; db170100. https://doi.org/10.2337/db17-0100

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    2017-07-21 yzh409
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encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Dec 23 04:45:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901617, encodeId=449a190161e1d, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Aug 14 17:45:00 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194040, encodeId=e9ea1940409d, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, 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objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 05 08:11:52 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192136, encodeId=75b0192136de, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 30 11:42:48 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191479, encodeId=59e21914e9da, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri Apr 28 12:54:13 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383285, encodeId=0c55138328559, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417286, encodeId=9932141e286e9, content=<a href='/topic/show?id=266826884bf' target=_blank style='color:#2F92EE;'>#依帕列净#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1911102, encodeId=ca8b191110260, content=<a href='/topic/show?id=8c0d2e73196' target=_blank style='color:#2F92EE;'>#健康人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27731, encryptionId=8c0d2e73196, topicName=健康人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55f6293, createdName=lishizhe, createdTime=Wed Jul 12 04:45:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696276, encodeId=3d9316962e69e, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 05 08:11:52 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192136, encodeId=75b0192136de, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 30 11:42:48 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191479, encodeId=59e21914e9da, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri Apr 28 12:54:13 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383285, encodeId=0c55138328559, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417286, encodeId=9932141e286e9, content=<a href='/topic/show?id=266826884bf' target=_blank style='color:#2F92EE;'>#依帕列净#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-05-05 绛珠草小姐

    学习了,谢谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1911102, encodeId=ca8b191110260, content=<a href='/topic/show?id=8c0d2e73196' target=_blank style='color:#2F92EE;'>#健康人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27731, encryptionId=8c0d2e73196, topicName=健康人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55f6293, createdName=lishizhe, createdTime=Wed Jul 12 04:45:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696276, encodeId=3d9316962e69e, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 05 08:11:52 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192136, encodeId=75b0192136de, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 30 11:42:48 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191479, encodeId=59e21914e9da, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri Apr 28 12:54:13 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383285, encodeId=0c55138328559, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417286, encodeId=9932141e286e9, content=<a href='/topic/show?id=266826884bf' target=_blank style='color:#2F92EE;'>#依帕列净#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26884, encryptionId=266826884bf, topicName=依帕列净)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0353248055, createdName=DEXTER3140, createdTime=Tue Apr 25 05:45:00 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-04-30 绛珠草小姐

    学习了,谢谢分享

    0

  8. 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    2017-04-28 绛珠草小姐

    学习了,谢谢分享

    0

  9. 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