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Heart:女性生育因素可影响心血管疾病发生风险

2018-06-25 MedSci MedSci原创

既往研究报道女性生育因素与心血管疾病(CVD)发生风险呈相关性,但结果一致性较差。本研究的目的旨在评估英国地区女性生育因素与CVD发生的相关性。2006年至2010年,英国生物样本库招募了超过500000名40-69岁的女性,经过7年时间的随访,共有9054例CVD事件发生(女性占34%),5782例冠心病事件发生(女性占28%),3489例卒中事件发生(女性占43%),通过Cox回归模型分析了C

既往研究报道女性生育因素与心血管疾病(CVD)发生风险呈相关性,但结果一致性较差。本研究的目的旨在评估英国地区女性生育因素与CVD发生的相关性。

2006年至2010年,英国生物样本库招募了超过500000名40-69岁的女性,经过7年时间的随访,共有9054例CVD事件发生(女性占34%),5782例冠心病事件发生(女性占28%),3489例卒中事件发生(女性占43%),通过Cox回归模型分析了CVD、冠心病和卒中事件与生育因素的危险比(HRs)。分析结果显示,对于CVD,初潮年龄过早(<12岁)的HRs为1.10(95%Cl 1.01-1.30),初次分娩年龄每早1年的HRs为0.97 (0.96-0.98),每次流产的HRs为1.04 (1.00-1.09),每次死胎的HRs为1.14 (1.02-1.28),更年期过早(<47岁)的HRs为1.33 (1.19-1.49)。另外,每增加一个小孩,CVD在女性的HR为1.03 (1.00-1.06),男性为1.03 (1.02 -1.05)。

本研究结果显示,初潮早、绝经早、初产年龄早、流产史、死胎或子宫切除史与女性心血管疾病风险的增加呈相关性。

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    2018-06-28 大爰

    学习并分享!!

    0

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    2018-06-27 zhaojie88
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    2018-06-27 slcumt

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