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牙科患者的福音:干细胞或可使牙髓再生!

2018-02-08 Bonnie,Juka 转化医学网

根管治疗术又称牙髓治疗,是牙医学中治疗牙髓坏死和牙根感染的一种手术。根管治疗术十分繁琐,一般要2-4次就诊才能完成,病人要承受的痛苦也较大。如果消毒不彻底,牙髓腔再次感染,还是要拔牙。罗格斯大学正在进行的一项研究或许能够使牙科患者不再恐惧根管治疗术。


根管治疗术又称牙髓治疗,是牙医学中治疗牙髓坏死和牙根感染的一种手术。根管治疗术十分繁琐,一般要2-4次就诊才能完成,病人要承受的痛苦也较大。如果消毒不彻底,牙髓腔再次感染,还是要拔牙。罗格斯大学正在进行的一项研究或许能够使牙科患者不再恐惧根管治疗术。

罗格斯牙科学院(RSDM)口腔生物学系的教授Shimizu正在研究如何使用干细胞再生牙髓,而不是在根管治疗期间将其移除。

这给我们带来一个好消息和一个坏消息。好消息是由于她的研究,根管治疗花费时间更少,并且干细胞生成的牙髓将大大降低感染和并发症风险。坏消息是牙科患者还是需要接受手术以取出感染的组织。

大家或许对牙髓、根管、根管治疗术这些名词不太熟悉,小转先来解释下这些词。

何谓牙髓?何谓根管?

牙齿中间空洞的部分包含称为牙髓的软组织。空洞上部宽阔,称为牙髓腔,下部有管状的根管,由之导出牙神经和营养神经的血管。一般每颗牙齿有1-4个根管。

牙髓组织主要包含神经、血管、淋巴和结缔组织,还有排列在牙髓外周的造牙本质细胞,其作用是造牙本质。当牙冠某一部位有龋洞或其它病损时,可在相应的髓腔内壁形成一层牙本质,以修复牙本质,补偿该部的牙冠厚度。

何谓根管治疗术?

当受损牙齿的感染或损伤从牙齿表面穿过牙齿根部进入周围神经组织时,需要进行根管治疗。经过一系列的手术准备之后,牙科医生将牙齿钻开,取出感染坏死的牙髓,再用合成材料填充空洞,最后用牙冠盖住牙齿。

虽然根管治疗术后,牙齿仍然存在,但基本上已经死亡。因为牙髓维持牙齿的健康,没有牙髓就意味着没有神经来识别疼痛和牙齿营养缺乏,牙齿就容易受到伤害、容易长蛀牙。

希望:干细胞或可使牙髓再生

Shimizu致力于使干细胞再生为牙髓。她从患者皮肤或头发分离干细胞,并把它们培养为由牙本质的神经系统、牙釉质下面的硬骨组织组成的血管网络。

日本研究人员在牙髓坏死的再生方面取得了进展,但是由于他们的研究只是使牙髓组织复活,而不是被新的牙髓取代,所以只能使年轻患者的牙髓组织更健壮。而且,用于再生牙髓的干细胞只能从婴儿牙齿或智齿中取得,这意味着这些细胞必须以高成本储存多年。
 
上个月,Shimizu获得批准,开始对老鼠进行测试,最终也会进行临床试验。

那么,不久的将来,需要做根管治疗术的牙科患者们可能就不会那么痛苦了。

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    2018-11-11 jxrzshh
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    2018-02-11 杨柳青青

    签到学习了--

    0

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    2018-02-11 1e207054m17(暂无匿称)

    非常好.谢谢分享

    0

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    2018-02-10 杨柳青青

    签到学习了--

    0

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    2018-02-10 jihuaijun1112

    学习学习学习

    0

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    2018-02-10 xzw115
  8. [GetPortalCommentsPageByObjectIdResponse(id=1669641, encodeId=ee84166964138, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Sun Nov 11 23:15:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287111, encodeId=724d28e111bc, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 11 16:40:59 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286926, encodeId=2fca28692654, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Sun Feb 11 03:03:04 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286880, encodeId=7add286880fa, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Feb 10 22:21:30 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286823, encodeId=af1628682345, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Feb 10 15:13:49 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417501, encodeId=f79a141e50117, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sat Feb 10 12:15:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461328, encodeId=d8df1461328d7, content=<a href='/topic/show?id=67356e62003' target=_blank style='color:#2F92EE;'>#牙科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67620, encryptionId=67356e62003, topicName=牙科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d786418402, createdName=xzw115, createdTime=Sat Feb 10 12:15:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286584, encodeId=df89286584e4, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Feb 09 18:31:14 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286480, encodeId=30d5286480b2, content=很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Feb 09 09:20:50 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286388, encodeId=64d228638818, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Fri Feb 09 03:29:03 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 杨柳青青

    签到学习了--

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1669641, encodeId=ee84166964138, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Sun Nov 11 23:15:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287111, encodeId=724d28e111bc, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 11 16:40:59 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286926, encodeId=2fca28692654, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Sun Feb 11 03:03:04 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286880, encodeId=7add286880fa, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Feb 10 22:21:30 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286823, encodeId=af1628682345, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Feb 10 15:13:49 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417501, encodeId=f79a141e50117, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sat Feb 10 12:15:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461328, encodeId=d8df1461328d7, content=<a href='/topic/show?id=67356e62003' target=_blank style='color:#2F92EE;'>#牙科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67620, encryptionId=67356e62003, topicName=牙科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d786418402, createdName=xzw115, createdTime=Sat Feb 10 12:15:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286584, encodeId=df89286584e4, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Feb 09 18:31:14 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286480, encodeId=30d5286480b2, content=很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Feb 09 09:20:50 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286388, encodeId=64d228638818, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Fri Feb 09 03:29:03 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 李东泽

    很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累.

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1669641, encodeId=ee84166964138, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Sun Nov 11 23:15:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287111, encodeId=724d28e111bc, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 11 16:40:59 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286926, encodeId=2fca28692654, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Sun Feb 11 03:03:04 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286880, encodeId=7add286880fa, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sat Feb 10 22:21:30 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286823, encodeId=af1628682345, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Sat Feb 10 15:13:49 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417501, encodeId=f79a141e50117, content=<a href='/topic/show?id=84ff6e663c4' target=_blank style='color:#2F92EE;'>#牙髓再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67663, encryptionId=84ff6e663c4, topicName=牙髓再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cf73291723, createdName=zhixianchen, createdTime=Sat Feb 10 12:15:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461328, encodeId=d8df1461328d7, content=<a href='/topic/show?id=67356e62003' target=_blank style='color:#2F92EE;'>#牙科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67620, encryptionId=67356e62003, topicName=牙科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d786418402, createdName=xzw115, createdTime=Sat Feb 10 12:15:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286584, encodeId=df89286584e4, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Fri Feb 09 18:31:14 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286480, encodeId=30d5286480b2, content=很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Feb 09 09:20:50 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286388, encodeId=64d228638818, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cee2018203, createdName=1e207054m17(暂无匿称), createdTime=Fri Feb 09 03:29:03 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 1e207054m17(暂无匿称)

    非常好.谢谢分享

    0

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以色列哈德拉以色列技术研究院拉帕波特医学研究所的Nasser W近日在Cell Rep发表了一项重要的文章,他们通过转基因小鼠发现,已经特化的角膜细胞具有可塑性,可以去分化重新产生干细胞群,并且可以在基质完好的存在的情况下,重新形成组织边界。

JACC:人胚胎干细胞来源的心脏祖细胞可用于临床治疗

人类胚胎干细胞(hESCs)由于其全能性,可以定向分化为不同组织特异性的细胞。本研究的目的旨在利用人类胚胎干细胞的特性分化出临床级别的心血管祖细胞,并对其应用在严重缺血性左心功能不全患者上的安全性进行评估。本研究共纳入了6名心功能不全患者(平均年龄66.5岁,平均左室射血分数为26%),所有患者均接受了载有平均820万个hESC来源的心血管祖细胞的纤维蛋白补片治疗,主要终点事件是患者术后1年的安全

Nat Commun:科学家用皮肤细胞培养出人体肌肉

在一个新研究项目中,美国杜克大学的生物工程师们展示了如何利用诱导多能干细胞培养出具有功能的人体肌肉。这是科学家们第一次证明从零开始培养人体肌肉组织是可能的,只需要诱导皮肤细胞成为干细胞,然后再用这些细胞生成肌肉组织。该研究发表在《Nature Communications》期刊上。

Nature子刊:找到干细胞靶向修复损伤心脏的新方法

导读:心肌梗死可引起心脏的大面积损伤,逐步发展为心力衰竭。干细胞是促进梗死心脏心肌再生的有效方法,但是缺乏治疗靶向性。美国北卡州立大学/北卡教堂山分校的最新一项研究表明,可以利用血小板修饰干细胞靶向修复损伤心脏。这一创新研究由美国北卡州立大学/北卡教堂山分校的程柯教授带领团队完成。他们研发出血小板纳米颗粒,用于修饰心脏干细胞,指引干细胞靶向受损心脏,并停留在损伤区域,从而增强干细胞的修复能力。相关

Cell Stem Cell:高胆固醇水平竟会加速干细胞增殖,使肠道肿瘤生长加速100倍

哎这夏天的时候啊,下了班约上三两好友,路边马扎一坐,叫上几手串儿配个扎啤,感觉一天的疲惫都在侃大山里消散殆尽了,整个人又充满了活力。

Angew Chem Int Edi:鉴别肿瘤干细胞 全新传感器火眼金睛

大多数癌症死亡由复发或转移性肿瘤导致。常规治疗靶向快速分裂的肿瘤细胞,但无法根除高度耐药的肿瘤干细胞,最终造成身体其他部位的肿瘤复发和扩散。韩国基础科学研究院(IBS)内的自组装和复杂性中心开发了首个显现肿瘤干细胞的荧光传感器。其在肺、中枢神经系统、黑色素瘤、乳腺、肾、卵巢、结肠和前列腺癌细胞培养中起作用。

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