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Arthritis Rheumatol:平板运动对大鼠骨关节炎疼痛的影响

2017-06-30 xiangting MedSci原创

在晚期NSAID治疗无效的OA中,运动可以通过增加内源性阿片样物质信号传导来缓解疼痛。

骨关节炎(OA)疼痛的患者常被推荐进行锻炼。然而,运动是否有益于改善持续性,非甾体抗炎药(NSAIDs)治疗无效,并与晚期OA相关的疼痛仍是未知的。

关节内(IA)碘代醋酸钠(MIA)或盐水治疗的大鼠进行平板运动或注射后10天开始保持久坐。评估触觉感觉阈值和体重,然后每周拍片。运动4周后,对IA或延髓头端腹内侧(RVM)注射利多卡因的大鼠使用条件性位置偏好(CPP)评估疼痛。通过全身注射纳洛酮检查内源性阿片样物质在运动诱发的疼痛缓解中的可能作用。用微计算机断层扫描(micro-CT)分析收集膝关节情况,以检查软骨下骨和胫骨干骺端的病理变化。

4周的平板运动反转了MIA引起的触觉超敏反应和体重不对称。在MIA注射后,IA和RVM利多卡因D35在久坐但未经MIA治疗的大鼠中诱发CPP,表明运动阻断MIA引起的持续疼痛。纳洛酮在运动的MIA大鼠中重新建立重量不对称性并诱导条件性反应,表明运动诱发的疼痛缓解依赖于内源性阿片样物质。运动没有改变OA的影像学证据。然而,微CT分析表明,运动并不阻断软骨下骨或小梁骨丢失,但阻断了MIA引起的内侧骨丢失。

这些发现支持结论:在晚期NSAID治疗无效的OA中,运动可以通过增加内源性阿片样物质信号传导来缓解疼痛。此外,平板运动阻断了该模型中的MIA引起的骨质流失,表明运动对OA关节的潜在骨稳定作用。

原始出处:
Joshua Allen,et al. Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats. Arthritis Rheumatol. July 2017.

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    2017-10-21 lisa438
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    2017-07-03 李东泽

    很好,不错,以后会多学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2066187, encodeId=80c1206618e7f, content=<a href='/topic/show?id=5f1e1016006d' target=_blank style='color:#2F92EE;'>#骨关节炎疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101600, encryptionId=5f1e1016006d, topicName=骨关节炎疼痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Fri Feb 02 12:05:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026534, encodeId=4e182026534f5, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sat Oct 21 02:05:00 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972402, encodeId=58bc19e240286, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Mon May 28 14:05:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923950, encodeId=a8a2192395030, content=<a href='/topic/show?id=64073011e18' target=_blank style='color:#2F92EE;'>#关节炎疼痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30117, encryptionId=64073011e18, topicName=关节炎疼痛)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Thu Jun 07 08:05:00 CST 2018, time=2018-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218063, encodeId=fe09218063c9, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Jul 03 09:06:33 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265455, encodeId=122c1265455c0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sun Jul 02 07:05:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356384, encodeId=f5dd135638451, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jul 02 07:05:00 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-02 lmm397
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    2017-07-02 zhaojie88

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